Laryngeal Sensorimotor Control in Parkinson's Disease

帕金森病的喉部感觉运动控制

• 批准号: 7026968
• 负责人: Michael J Hammer
• 金额: $ 2.89万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7026968
• 关键词: Parkinson' s disease; clinical research; human subject; larynx disorder; pathologic process; patient oriented research; predoctoral investigator; sensory thresholds; speech disorders; vocalization

DESCRIPTION (provided by applicant): Normal speech production is relegated to near automaticity and is dependent upon a highly coordinated coupling of motor output with sensory input from auditory and somatosensory (i.e., sensory inputs from skin, mucosa, muscle and joint receptors) systems. Models of sensorimotor dysfunction, such as Parkinson's disease (PD), demonstrate substantially impoverished sensorimotor integration and degradation of motor control; however, few studies have examined the relationship between changes in sensorimotor integration with speech motor control in diseases such as PD. This study will use laryngeal sensory detection thresholds and laryngeal aerodynamics to examine the relationship between sensorimotor integration and control of speech-related laryngeal movements in a group of patients with idiopathic Parkinson's disease and a group of normal controls. The specific aims of this study address three questions: (1) Do individuals with PD exhibit different timing of vocal fold medialization than normal controls? (2) Do individuals with PD exhibit different laryngeal sensory detection thresholds than normal controls? (3) What is the relationship between timing of vocal fold medialization and laryngeal sensory detection thresholds? The long-term goal is to improve our understanding of the role of somatosensory input in the precision of speech-related laryngeal movements and how these precise movements are disrupted by changes in sensory integration.

描述（由申请人提供）：正常的言语产生被归入近自动性，并且依赖于运动输出与来自听觉和躯体感觉的感觉输入的高度协调的耦合（即，来自皮肤、粘膜、肌肉和关节受体的感觉输入）系统。感觉运动功能障碍的模型，如帕金森氏病（PD），表现出实质上贫困的感觉运动整合和运动控制的退化;然而，很少有研究探讨感觉运动整合的变化与疾病，如PD的言语运动控制之间的关系。本研究将使用喉感觉检测阈值和喉空气动力学检查一组原发性帕金森病患者和一组正常对照组的感觉运动整合和控制语音相关的喉运动之间的关系。本研究的具体目的是解决三个问题：（1）与正常对照组相比，PD个体是否表现出不同的声带内侧化时间？(2)PD患者是否表现出与正常对照组不同的喉感觉检测阈值？(3)声带内侧化的时间与喉感觉检测阈值有何关系？长期目标是提高我们对躯体感觉输入在与语音相关的喉部运动的精确性中的作用的理解，以及这些精确的运动如何被感觉整合的变化所破坏。