The molecular basis of olfaction in Drosophila larvae

果蝇幼虫嗅觉的分子基础

• 批准号: 7113764
• 负责人: Scott A KREHER
• 金额: $ 0.98万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113764
• 关键词: Drosophilidae; chemoreceptors; genetically modified animals; larva; molecular genetics; neurogenetics; neurophysiology; olfactions; predoctoral investigator

DESCRIPTION (provided by applicant): Animals use their olfactory sensory systems to interact with the complex and heterogeneous environment. Although we have discovered much about how olfactory systems work, we still do not well understand how an odor is translated into information in the brain. The Drosophila larva is an ideal system in which to test hypotheses about odor coding. Larvae have few olfactory receptor neurons, yet display sophisticated olfactory mediated behaviors. I propose an examination of olfactory receptors in Drosophila larvae using genetic, behavioral, and physiological analysis. I will test the hypothesis that Odorant receptor (Or) genes act as olfactory receptors in the larva. Furthermore, I plan to test the contribution of Or genes to olfactory behavior in the larvae.

描述（申请人提供）：动物利用其嗅觉系统与复杂且异质的环境进行互动。虽然我们已经发现了很多关于嗅觉系统如何工作的知识，但我们仍然不太了解气味如何在大脑中转化为信息。果蝇幼虫是检验气味编码假说的理想系统。仔鱼的嗅觉感受神经元很少，但表现出复杂的嗅觉介导的行为。我提出了一个检查果蝇幼虫的嗅觉受体遗传，行为和生理分析。我将测试的假设，气味受体（或）基因作为嗅觉受体的幼虫。此外，我计划测试Or基因对幼虫嗅觉行为的贡献。