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Functional analysis of novel honey bee neuropeptide genes using Drosophila

利用果蝇对新型蜜蜂神经肽基因进行功能分析

基本信息

批准号：
7485418
负责人：
Scott A KREHER
金额：
$ 3.59万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-11-16 至 2009-08-04
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7485418
关键词：
Affect Afferent Neurons Animals Apis Autistic Disorder Bees Behavior Behavioral Biological Assay Brain Brain region Caenorhabditis elegans Candidate Disease Gene Caring Code Color Complex Computer information processing Courtship Dancing Development Discrimination Disease Drosophila genus Drosophila melanogaster Employee Strikes Esophageal Ganglia Genes Genetic Genetic Polymorphism Genome Goals Grooming Honey Human In Situ In Situ Hybridization Individual Insecta Juvenile Hormones Language Left Lobe Modeling Molecular Molecular Genetics Mus Mushroom Bodies Myxoid cyst Nature Neuropeptide Gene Neuropeptides Neuropil Numbers Octopamine Odors Optic Lobe Orthologous Gene Pathway interactions Pattern Phenotype Play RNA I RNA Interference RNA Probes Regulation Research Resources Retina Role Sensory Signal Transduction Signaling Molecule Social Behavior Standards of Weights and Measures System Taxon Techniques Testing Transcript Transgenic Organisms Urticaria Variant Vitellogenins Work base comparative experience feeding fly gene function genetic manipulation innovation knock-down neural circuit novel receptor research study social social group sugar tool visual process visual processing

项目摘要

DESCRIPTION (provided by applicant): Social behavior occurs across animal taxa and in a spectrum of organization, from aggregation behaviors in C. elegans to the exquisitely organized colonies of social insects. The honey bee (Apis mellifera) is a highly social insect, which shows many important behaviors in common with humans, such as parental care of young and a symbolic dance language. With the recent sequencing of the honey bee genome, it is now easier to conduct molecular studies. The honey bee has a rich repertoire of behaviors, yet molecular and genetic manipulation techniques are still immature. An alternative approach to this problem is to take advantage of the experimental techniques of the fruit fly, Drosophila melanogaster. The honey been genome contains multiple genes which appear to encode neuropeptides, but have unknown functions and appear to be novel in the honey bee. These novel neuropeptide genes will be expressed in the fruit fly and simple behaviors will be systematically tested. The hypothesis will be examined that these genes may play a role in the organization of social behavior. Humans exist in social groups and social behavior diseases, such as autism, are poorly understood. By understanding the possible role of neuropeptide genes in complex behavior in the honey bee, we may be able to understand in general terms how genes underlie complex behaviors in humans.

描述（由申请人提供）：社会行为发生在动物类群和组织的光谱，从聚集行为在C。从优雅线虫到社会性昆虫的精致群体。蜜蜂（Apis mellifera）是一种高度社会化的昆虫，它表现出许多与人类相似的重要行为，如父母照顾幼崽和象征性的舞蹈语言。随着最近蜜蜂基因组的测序，现在更容易进行分子研究。蜜蜂有丰富的行为，但分子和遗传操纵技术仍不成熟。解决这个问题的另一种方法是利用果蝇（Drosophila melanogaster）的实验技术。蜜蜂基因组包含多个似乎编码神经肽的基因，但功能未知，在蜜蜂中似乎是新的。这些新的神经肽基因将在果蝇中表达，简单的行为将被系统地测试。这些基因可能在社会行为的组织中发挥作用的假设将被检验。人类存在于社会群体中，对自闭症等社会行为疾病的了解很少。通过了解神经肽基因在蜜蜂复杂行为中的可能作用，我们可能能够大致了解基因是如何构成人类复杂行为的基础的。