权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Joint Discoordination in Parkinson's Disease

帕金森病的关节不协调

基本信息

批准号：
7001296
负责人：
NATALIA V DOUNSKAIA
金额：
$ 28.71万
依托单位：
ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-01-15 至 2008-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7001296
关键词：
Joint Discoordination Parkinson Disease

项目摘要

DESCRIPTION (provided by applicant): Evidence indicates that Parkinson's Disease (PD) patients are particularly impaired in the performance of complex movements that require coordination of several joints. Studying these impairments is of considerable practical importance, because movements performed in everyday life (reaching, grasping, pointing, lifting, etc) are essentially multi-joint and the lack of coordination is one of the most debilitating aspects of the disease. Many studies have hypothesized that impairments in multi-joint movements arise from difficulties patients have in controlling several joints simultaneously. Data obtained in our lab suggest that the reason for multi-joint movement distortions in PD is different. We argue that PD patients have difficulties in the regulation of interactive torques. These torques may be considered as the effect of constraints imposed by peripheral biomechanics on control of the limbs. Healthy older adults overcome these constraints at normal movement speeds. Our data suggest that PD patients are unable to deal with the biomechanical constraints during movements of moderate and even low speeds. The purpose of the present proposal is (1) to demonstrate that the inability to properly regulate interactive torques is the major cause of multi-joint movement disruptions in PD, (2) to establish how interactive torques affect control at individual joints in multi-joint movements of the patients, and (3) to examine plausible reasons for the inability of patients to coordinate muscle torques necessary to modulate interactive torques at the joints. Our experiments utilize various arm movements, which manipulate joint coordination patterns stressing different roles of interactive torques in the control of joint movements. The data obtained in our experiments will provide important scientific and clinical contributions into knowledge of basal ganglia dysfunctions.

描述（由申请人提供）：证据表明，帕金森病（PD）患者在进行需要协调多个关节的复杂运动时尤其受损。研究这些损伤具有相当大的实际重要性，因为日常生活中进行的运动（达到，抓握，指向，提升等）基本上是多关节的，缺乏协调是疾病最虚弱的方面之一。许多研究假设，多关节运动障碍是由于患者难以同时控制多个关节。我们实验室获得的数据表明，PD中多关节运动失真的原因是不同的。我们认为，PD患者有困难的相互作用扭矩的调节。这些扭矩可以被认为是外周生物力学对肢体控制施加的约束的效果。健康的老年人以正常的运动速度克服这些限制。我们的数据表明，PD患者是无法处理的生物力学限制在运动的中等，甚至低速。本提案的目的是（1）证明不能适当地调节交互扭矩是PD中多关节运动中断的主要原因，（2）确定交互扭矩如何影响患者多关节运动中各个关节处的控制，和（3）检查患者不能协调调节关节处相互作用扭矩所需的肌肉扭矩的合理原因。我们的实验利用各种手臂运动，操纵关节协调模式强调不同的作用，相互作用的扭矩在控制关节运动。在我们的实验中获得的数据将提供重要的科学和临床贡献到知识的基底神经节功能障碍。