Phase behaviour and disruption in model bacterial cell envelopes

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Gram-negative bacteria are a major health threat due to their rapidly increasing resistance to antibiotics. A key aspect of this resistance is the protective outer membrane that surrounds these bacteria. Scientifically, this outer membrane is interesting because of the different soft matter states it may represent. Technically, however, it is challenging to investigate the outer membrane at the relevant molecular length scales. In this project, we will overcome this challenge by developing and characterising model systems with which we can vary and study multiple aspects of this outer membrane. These model systems can next be used as a testbed for next-generation antibiotics.