Hemotologic and Oncologic Diseases of Childhood

描述(由申请人提供)： 我们建议提供一项机构培训赠款，以培训医生/科学家，他们将为改善血液疾病和恶性肿瘤儿童的诊断、治疗和预防策略做出贡献。研究员将在爱荷华州儿童医院和罗伊·J·卡弗医学院和露西尔·A·卡弗医学院接受翻译或临床研究方面的培训。爱荷华大学是一个学术医疗中心的所在地，该中心为以农村家庭为主的大片地理区域提供全方位的医疗保健，包括三级服务。一小部分快速增长的少数民族人口也在我们的集水区生活和工作，并在我们的机构接受照顾。我们的农村环境提供了独特的机会，既可以培训儿童血液病和恶性疾病方面的儿科专家，也可以让这些儿童参加临床试验。我们提出了以下目标：1.扩大受训人员追求学术生涯的机会，重点是血液病和儿童恶性疾病。爱荷华州儿科拥有一项经认可的血液学/肿瘤学ACGME奖学金计划，并在招聘高素质儿科医生方面建立了良好的记录，这些医生随后将从事学术医学事业。在这项申请中，我们提出了一个机构培训计划，专注于血液病或恶性疾病儿童的转化性和临床研究。我们系目前有NICHD新生儿生物学培训补助金和NHLBI儿科心脏病学培训补助金，因此提供了重要的培训支持，包括建立了所有儿科专科研究员都参与的午餐讨论系列，以及专门在爱荷华州制定的独特的奖学金评估计划。通过这种方式，整个爱荷华州儿科教职员工将与内科、精神病学、神经学、解剖学和细胞生物学、微生物学、生理学、麻醉学、放射学、放射生物学和外科的经验丰富的导师合作，提供导师团队，在专注于儿童血液或肿瘤疾病的翻译或临床研究方面提供平衡的培训计划。公共卫生学院的教员参与了K-30项目以及我们的正式评估项目。2.为学员提供获得转化医学或临床医学硕士或非学位证书的机会。每个研究员的核心课程将集中在提供临床研究硕士学位的爱荷华大学K-30课程，或我们独特的爱荷华大学翻译研究研究生课程。我们在基础医学方面拥有公认的专业知识，在我们建议的指导团队中，我们在临床研究方面的专业知识也在不断增长。综合起来，这些优势将构成我们在翻译或临床研究方面建立培训计划的基础。因此，除了以患者为中心的研究方面的认证或硕士学位之外，每个研究员都将制定一个单独的研究计划，该计划具有足够的初步数据，以在完成奖学金时提交K-23奖励。3.招募和培训妇女从事有利于患有血液和肿瘤疾病的儿童的成功职业。进入医学界的女性人数正在稳步增加。在儿科住院医师计划中，这一点最为明显。不幸的是，在学术儿科和儿科次级专科，如儿科血液学/肿瘤学的妇女人数没有增加。在爱荷华州，我们培养了一支由32名导师组成的强大团队，其中包括15名拥有积极研究项目的女性教职员工，她们将在指导方法中解决女性的特殊需求。我们建议开设授课课程、小组讨论和额外的个人辅导机会，以支持寻求学术生涯的女性。(摘要结束)

DESCRIPTION (provided by applicant): We propose an institutional training grant to train physician/scientists who will contribute to improved diagnostic, treatment and prevention strategies for children with blood diseases and malignancies. Fellows will train in either translational or clinical research at the Children's Hospital of Iowa and the Roy J. and Lucille A. Carver College of Medicine. The University of Iowa is home to an academic medical center that provides the full range of health care including tertiary services for a large geographic area of predominantly rural families. A small, rapidly growing, minority population also lives and works in our catchment area and receives care in our institution. Our rural environment offers unique opportunities both for training pediatric subspecialists regarding hematologic and malignant diseases afflicting these children and for enrolling these children in clinical trials. We propose the following goals: 1. Expand opportunities for trainees to pursue academic careers with a focus on hematologic and malignant diseases of childhood. The Iowa Department of Pediatrics has an accredited ACGME fellowship program in hematology/oncology and has established a track record of recruiting highly qualified pediatricians who then pursue a career in academic medicine. In this application, we propose an institutional training program to focus on translational and clinical research in children with hematologic or malignant diseases. Our department currently has an NICHD training grant in neonatal biology and a NHLBI training grant in pediatric cardiology, thus providing important training support, including an established luncheon discussion series in which all pediatric subspecialty fellows participate, and a unique fellowship evaluation program specifically developed at Iowa. In this way, the entire Iowa Department of Pediatrics faculty will work together with experienced mentors in internal medicine, psychiatry, neurology, anatomy & cell biology, microbiology, physiology, anesthesia, radiology, radiation biology, and surgery to provide mentoring teams that provide a balanced training program in translational or clinical research that focuses on hematologic or oncologic diseases of childhood. Faculty in the College of Public Health participate in the K-30 program as well as in our formal evaluation program. 2. Provide trainees with the opportunity to obtain a Master's degree or non-degree certification in either translational or clinical medicine. The core curriculum for each fellow will be concentrated in either the University of Iowa K-30 program offering a master's in clinical research or in our unique University of Iowa graduate program in translational research. We have a well recognized expertise in basic medical science, as well as a growing expertise in clinical research among our proposed mentoring teams. Together, these strengths will form the foundation on which we will build a training program in translational or clinical research. Thus, in addition to certification or a master's degree in patient-oriented research, each fellow will have developed an individual research plan with sufficient preliminary data to submit a K-23 award at the completion of the fellowship. 3. Recruit and train women for successful careers that will benefit children with hematologic and oncologic disorders. The number of women entering medicine is steadily increasing. Nowhere is this more evident than in pediatric residency programs. Unfortunately, the number of women in academic pediatrics and in pediatric subspecialties such as pediatric hematology/oncology is not increasing. At Iowa, we have developed a strong group of 32 mentors, including 15 women faculty with active research programs, who will address the special needs of women in their mentoring approach. We propose didactic sessions, group discussions and additional individual mentoring opportunities to support women seeking academic careers. (END OF ABSTRACT)