Training in Synaptic Neurobiology

突触神经生物学培训

• 批准号: 7096532
• 负责人: JAMES R BAMBURG
• 金额: $ 19.29万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7096532
• 关键词: Training; Synaptic; Neurobiology

DESCRIPTION (provided by applicant) Integrated investigations using methods from biochemistry, molecular biology, cell biology, anatomy and physiology are central to advancing our understanding of synapse formation, organization and function. The purpose of the proposed program is to provide postdoctoral and predoctoral training focused in synaptic neurobiology. Our strategy for training gains from its ability to emphasize a specific set of current issues that require an interdisciplinary approach while still maintaining a breadth of training experience and exposure to a wide variety of intellectual tools. This research is the foundation for understanding - and hopefully alleviating - numerous neurological diseases. The training will be provided by 7 faculty members of the Molecular, Cellular and Integrative Neuroscience (MCIN) Program. The faculty members come from four departments in two colleges. These faculty, along with 14 others, have organized and teach a core neurobiology curriculum offering lecture, literature, laboratory and discussion courses. Within the program are individuals who can apply this fundamental knowledge in actual treatment of neurological disorders, through their joint appointments as clinical scientists at the Colorado State University Veterinary Teaching Hospital. In 2000 - 2001, 15 predoctoral and 20 postdoctoral students received training in the laboratories of the training faculty. These trainees were supported from individual research grants, postdoctoral and graduate fellowships, and by graduate assistantships from the MCIN Program. Most of the predoctoral trainees have degrees in traditional disciplines and were recruited either through participating departments or through the MCIN program. All of the postdoctoral trainees initiated contact with their mentors directly and were not recruited. The program described in this proposal would allow us to recruit 4 postdoctoral trainees and support 2 predoctoral students to participate in cross-disciplinary projects involving more than one laboratory for up to 3 years. These recruits will be important for strengthening the interactions between laboratories and will provide the trainees with a unique opportunity to acquire the multidisciplinary skills needed for success in today's research environment. All trainees will have access to modern cell and molecular biological facilities including computer enhanced light, confocal and electron microscopy (intermediate voltage), combined electrophysiology and light/fluorescence microscopy equipment, macromolecular synthesis and sequencing facilities, gene cloning and cell transfection laboratories, and a high quality lab animal resource facility.

描述（由申请人提供） 使用生物化学、分子生物学方法进行综合研究， 细胞生物学、解剖学和生理学对于增进我们的理解至关重要 突触的形成、组织和功能。拟议的目的 计划是提供以突触为重点的博士后和博士前培训 神经生物学。我们的培训策略得益于它能够强调 需要采取跨学科方法的当前特定问题 仍然保持广泛的培训经验和广泛的接触 各种智力工具。这项研究是以下基础 了解并有望缓解多种神经系统疾病。这 培训将由 7 名分子、细胞和 综合神经科学（MCIN）计划。教职人员来自四位 两个学院的院系。这些教师以及其他 14 名教师 组织并教授核心神经生物学课程，提供讲座， 文学、实验和讨论课程。程序内有 能够将这些基础知识应用到实际治疗中的人 神经系统疾病，通过联合任命为临床科学家 在科罗拉多州立大学兽医教学医院。 2000年至2001年间， 15名博士生和20名博士后在该实验室接受培训 培训学院的实验室。这些学员得到了来自 个人研究补助金、博士后和研究生奖学金，以及 MCIN 项目的研究生助学金。大部分博士前实习生 拥有传统学科学位，并通过以下途径招聘 参与部门或通过 MCIN 计划。全部博士后 受训者直接与其导师联系，并未被招募。 该提案中描述的计划将允许我们招募 4 名博士后 并支持2名博士生参加 涉及多个实验室（最多 3 个）的跨学科项目 年。这些新成员对于加强互动非常重要 实验室之间，将为学员提供独特的机会 获得当今研究成功所需的多学科技能 环境。所有学员都将有机会接触现代细胞和分子 生物设施，包括计算机增强光、共焦和电子 显微镜（中压）、联合电生理学和 光学/荧光显微镜设备、高分子合成和 测序设施、基因克隆和细胞转染实验室以及 高品质的实验动物资源设施。