Injury Mechanisms and Related Responses

损伤机制及相关反应

• 批准号: 7062068
• 负责人: Ida Marie, DNSc Moore
• 金额: $ 8万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7062068
• 关键词: Injury; Mechanisms; Related; Responses

DESCRIPTION (provided by applicant): In 1993, the National Institute for Nursing Research announced a 10-year plan to increase the number of nurse researchers employing state-of-the-science biological techniques and methods in nursing studies. This 10-year plan resulted in a group of faculty members at The University of Arizona College of Nursing who study injury mechanisms and related responses to injury that are relevant to nursing and altered health conditions. Injury mechanisms are important to nursing because many disease processes (e.g. those related to cancer, stroke and HIV infection) and health problems (e.g. prolonged wound healing) involve injury to healthy cells, tissues and organs. Biological (e.g. muscle wasting and cancer metastasis) and/or behavioral (e.g. depression, fatigue and cognitive impairments) responses to injury are also important, because they can adversely affect outcomes from altered health conditions. In this application, related responses refer to biological and/or behavioral responses to injury mechanisms. Our goal for this institutional training application is to increase the number of nurse scientists who will advance nursing science in this focus area. The purpose is to train 3 predoctoral and 2 postdoctoral fellows each year with the necessary theoretical and methodological expertise to: 1. Advance knowledge about mechanisms of injury and/or about related responses to injury that are relevant to nursing. 2. Incorporate state-of-the-science methods and techniques into nursing studies of injury mechanisms and/or related responses to injury. 3. Study the effects of interventions designed to: a) prevent or minimize tissue injury, and/or b) enhance positive biological or behavioral responses to injury mechanisms. Predoctoral fellows will also receive preparation in the academic role; postdoctoral fellows will receive mentorship on grant writing skills to prepare them for national extramural funding endeavors. Training experiences will be performed within The University of Arizona College of Nursing and relevant departments, colleges and laboratories. A post-baccalaureate "fast-track" program and more traditional post-masters program are available to predoctoral trainees. All will complete substantive coursework in Injury Mechanisms and Related Responses, theory, research, role development, a minor area and dissertation. Postdoctoral trainees will complete the substantive seminar in Injury Mechanisms and Related Responses, and other coursework as needed for the specific area of focus. All trainees will participate in seminars and will receive intensive mentored research training with a well matched sponsor/co-sponsor.

描述（由申请人提供）：1993年，美国国家研究所 护理研究宣布了一项为期10年的计划，以增加护士的数量 研究人员采用科学生物学技术和方法 护理研究。这个为期10年的计划导致了一群教职员工 亚利桑那大学护理学院研究伤害机制和 与护理和健康改变有关的伤害的相关反应 状况。伤害机制对护理很重要，因为许多疾病 过程（例如与癌症，中风和艾滋病毒感染有关的过程）和健康 问题（例如，长时间的伤口愈合）涉及对健康细胞的损伤， 组织和器官。生物学（例如肌肉浪费和癌症转移） 和/或行为（例如抑郁，疲劳和认知障碍） 对伤害的反应也很重要，因为它们可能会对 健康状况改变的结果。在此应用程序中，相关答复 请参阅对损伤机制的生物学和/或行为反应。我们的目标 对于此机构培训申请是增加护士的数量 将在这个焦点领域推进护理科学的科学家。目的是 每年训练3个载体前和2个博士后研究员 理论和方法论专业知识：1。提前了解 相关的伤害机制和/或有关伤害的相关反应 进行护理。 2。将科学方法和技术纳入 损伤机制和/或对伤害的相关反应的护理研究。 3。 研究旨在：a）预防或最小化组织的干预措施的影响 伤害和/或b）增强对损伤的积极生物学或行为反应 机制。托管前研究员也将在学术上接受准备 角色;博士后研究员将获得有关赠款写作技巧的指导 为他们准备国家的卫生资金努力。培训经验 将在亚利桑那大学护理学院内进行 相关部门，大学和实验室。后血统 可以使用“快速轨道”计划和更多传统的阶级计划 托管前学员。所有人都将完成受伤的实质性课程 机制和相关反应，理论，研究，角色发展，次要 区域和论文。博士后学员将完成实质性 伤害机制和相关反应的研讨会以及其他课程工作 特定重点领域需要。所有学员将参加 研讨会，并将接受深入的指导研究培训 匹配的赞助商/共同赞助商。

项目成果

Caregiving stress, immune function, and health: implications for research with parents of medically fragile children.

• DOI: 10.1080/01460860490884165
• 发表时间: 2004-10-01
• 期刊: Issues in comprehensive pediatric nursing
• 作者: Kuster, Patricia A;Merkle, Carrie J
• 通讯作者: Merkle, Carrie J

Caspase inhibition of platelet activation.

Caspase 抑制血小板活化。

• DOI: 10.1097/mbc.0b013e3283001cf5
• 发表时间: 2008
• 期刊: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
• 作者: Cohen,Zoe;Davis-Gorman,Grace;McDonagh,PaulF;Ritter,Leslie
• 通讯作者: Ritter,Leslie