NHLBI Respiration Biology Research Training Grant

描述(由申请人提供)： 呼吸系统疾病仍然是死亡和残疾的主要原因。呼吸生物学方面的培训将使年轻的研究人员为从事旨在消除这些主要致病和死亡原因的职业做好准备。该计划为医生或博士提供密集的研究培训，为独立调查人员的职业生涯做准备。在过去的资助期间，我们利用了明尼苏达州罗切斯特的梅奥诊所和亚利桑那州斯科茨代尔的梅奥诊所强大的联合研究培训专业知识。梅奥·罗切斯特大学胸科研究部主任安德鲁·H·林珀博士将继续担任项目主任，而梅奥·斯科茨代尔大学约翰逊研究中心的哮喘研究和转基因项目主任詹姆斯·J·李博士将担任联席主任。这一培训计划是我们综合研究和管理结构的自然延伸。两个校区都有发展良好、资金雄厚的研究团队。教员在医学系、生物化学/分子生物学系、免疫学系和生理学系担任学术职务。利用我们基于卫星的通信，主要会议在校园之间举行电话会议。此外，教职员工还经常往返于不同地点之间，执行教育、科学和行政职责。即时通信通过我们的集成寻呼和电话系统、视频链接和电子邮件实现。林珀博士和梅奥研究生院在指导学员在梅奥地点之间进行培训方面拥有丰富的经验。我们建议18名高级教员和6名副教员，研究人员分布在不同的地点。可用的研究课题包括宿主防御和肺部感染的生物学、哮喘和阻塞性肺疾病、细胞外基质和肺纤维化、囊性纤维化的分子基础、疾病的转基因动物模型、肺部炎症、细胞生物力学以及蛋白酶和脂肪生物化学。我们每年为四个实习生职位提供优秀的研究机会。具有医学博士、博士或医学博士、博士背景的合格候选人将被考虑。我们在招募任职人数不足的少数族裔方面已经取得重大成功，并将继续作出这些努力。应聘者承诺至少两年，但最好是三年或三年以上的全职研究。有多种教学课程可供选择，以补充密集的实验室经验。

DESCRIPTION (provided by applicant): Respiratory diseases remain a major cause of death and disability. Training in respiratory biology will prepare young investigators for careers directed at eliminating these major causes of morbidity and mortality. This program provides intensive research training for physicians or Ph.D.s to prepare for careers as independent investigators. Over the past funding period, we have utilized the strong combined research training expertise of the Mayo Clinic Rochester, MN and Mayo Clinic Scottsdale, AZ. Dr. Andrew H. Limper, director of the Thoracic Research Unit at Mayo Rochester, will continue as program director, while Dr. James J. Lee, director of asthma research and the transgenic program at the Johnson Research Center at Mayo Scottsdale, will act as co-director. This training program arises as a natural extension of our integrated research and administrative structure. Well-developed and competitively funded research teams are present at both campuses. Faculty members hold academic appointments in the Departments of Medicine, Biochemistry/Molecular Biology, Immunology, and Physiology. Utilizing our satellite-based communication, major conferences are teleconferenced between campuses. In addition, faculty routinely travel between sites for educational, scientific, and administrative duties. Immediate communication occurs via our integrated paging and telephone systems, video links, and electronic mail. Dr. Limper and the Mayo Graduate School have considerable experience in supervising trainees as they train between Mayo sites. We propose 18 senior and 6 associate faculty members, with the research faculty being divided between the sites. Available research topics range from the biology of host defense and pulmonary infections, asthma and obstructive lung disease, extracellular matrix and lung fibrosis, the molecular basis of cystic fibrosis, transgenic animal models of disease, lung inflammation, cellular biomechanics, and protease and lipid biochemistry. We propose outstanding research opportunities for four trainee positions per year. Qualified candidates with M.D., Ph.D., or M.D., Ph.D. backgrounds are considered. We have already had significant success in the recruitment of under-represented minorities and will continue these efforts. Candidate are committed to a minimum of two, but preferably three or more years of full time research. A wide range of didactic courses is available to complement the intensive laboratory experience.