NHLBI Respiration Biology Research Training Grant

描述（由申请人提供）： 呼吸道疾病仍然是死亡和残疾的主要原因。 呼吸生物学的培训将使年轻的研究人员为消除这些主要的发病和死亡原因做好准备。 该计划为医生或博士提供密集的研究培训，为独立调查员的职业生涯做准备。 在过去的资助期间，我们利用了明尼苏达州罗切斯特市马约诊所和亚利桑那州斯科茨代尔马约诊所强大的综合研究培训专业知识。 Andrew H.博士马约罗切斯特胸部研究中心主任林珀将继续担任项目主任，而马约斯科茨代尔约翰逊研究中心哮喘研究和转基因项目主任詹姆斯·J·李博士将担任联合主任。 该培训计划是我们综合研究和行政结构的自然延伸。 两个校区都有发达和有竞争力的研究团队。 教师在医学，生物化学/分子生物学，免疫学和生理学系担任学术职务。利用我们的卫星通信，主要会议是校园之间的电话会议。 此外，教师经常在教育，科学和行政职责之间旅行。 通过我们的综合寻呼和电话系统、视频链接和电子邮件进行即时通信。 Limper博士和马约研究生院在指导学员在马约地点之间进行培训方面有相当丰富的经验。 我们建议18名高级和6名副教员，研究教师被划分在网站之间。 现有的研究课题包括宿主防御和肺部感染的生物学、哮喘和阻塞性肺病、细胞外基质和肺纤维化、囊性纤维化的分子基础、疾病的转基因动物模型、肺部炎症、细胞生物力学以及蛋白酶和脂质生物化学。 我们每年为四个实习生职位提供出色的研究机会。 具有医学博士学位的合格人选，哲学博士、或者医学博士博士背景考虑。 我们在招聘代表性不足的少数民族方面已经取得了重大成功，并将继续这方面的努力。候选人承诺至少两年，但最好是三年或更长时间的全职研究。 广泛的教学课程可用于补充密集的实验室经验。

DESCRIPTION (provided by applicant): Respiratory diseases remain a major cause of death and disability. Training in respiratory biology will prepare young investigators for careers directed at eliminating these major causes of morbidity and mortality. This program provides intensive research training for physicians or Ph.D.s to prepare for careers as independent investigators. Over the past funding period, we have utilized the strong combined research training expertise of the Mayo Clinic Rochester, MN and Mayo Clinic Scottsdale, AZ. Dr. Andrew H. Limper, director of the Thoracic Research Unit at Mayo Rochester, will continue as program director, while Dr. James J. Lee, director of asthma research and the transgenic program at the Johnson Research Center at Mayo Scottsdale, will act as co-director. This training program arises as a natural extension of our integrated research and administrative structure. Well-developed and competitively funded research teams are present at both campuses. Faculty members hold academic appointments in the Departments of Medicine, Biochemistry/Molecular Biology, Immunology, and Physiology. Utilizing our satellite-based communication, major conferences are teleconferenced between campuses. In addition, faculty routinely travel between sites for educational, scientific, and administrative duties. Immediate communication occurs via our integrated paging and telephone systems, video links, and electronic mail. Dr. Limper and the Mayo Graduate School have considerable experience in supervising trainees as they train between Mayo sites. We propose 18 senior and 6 associate faculty members, with the research faculty being divided between the sites. Available research topics range from the biology of host defense and pulmonary infections, asthma and obstructive lung disease, extracellular matrix and lung fibrosis, the molecular basis of cystic fibrosis, transgenic animal models of disease, lung inflammation, cellular biomechanics, and protease and lipid biochemistry. We propose outstanding research opportunities for four trainee positions per year. Qualified candidates with M.D., Ph.D., or M.D., Ph.D. backgrounds are considered. We have already had significant success in the recruitment of under-represented minorities and will continue these efforts. Candidate are committed to a minimum of two, but preferably three or more years of full time research. A wide range of didactic courses is available to complement the intensive laboratory experience.