TAS::75 0872::TAS LUNG TISSUE RESEARCH CONSORTIUM CLINICAL CENTER

国家心肺血液研究所(NHLBI)肺组织研究联盟(LTRC)成立的主要目的是收集肺组织和血液样本，其次是收集慢性阻塞性肺疾病(COPD)、特发性肺纤维化(IPF)、其他相关特发性间质性肺炎(IIP)和与结缔组织病相关的间质性肺炎患者的临床数据、有限暴露数据、生理学研究和放射学研究。为了比较的目的，肺组织和类似的临床数据将从需要肺切除的对照受试者中收集。这些对照受试者将主要来自没有肺功能不良的癌症患者，他们的非肿瘤组织可以从结节或肿块远程收集，也可能来自登记的疑似间质性肺部疾病(ILD)患者，他们在病理检查后被证明没有这种疾病。所有组织和血液样本以及临床数据将被储存和储存，以便分发给未来的调查人员，这些调查人员已经批准了研究建议，并正在调查上述肺部疾病的发病机制。

The National Heart, Lung and Blood Institute (NHLBI) Lung Tissue Research Consortium (LTRC) was established with the primary purpose of collecting lung tissue and blood samples and a secondary purpose of collecting clinical data, limited exposure data, physiologic studies, and radiographic studies from patients with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), other related idiopathic interstitial pneumonias (IIP) and interstitial pneumonias associated with connective tissue diseases who undergo medically-indicated lung resection. For the purpose of comparison, lung tissue and similar clinical data will be collected from control subjects who require lung resection. These control subjects will primarily come from cancer patients without poor lung function for whom non-neoplastic tissue can be collected remotely from a nodule or mass and may also come from patients enrolled with suspected interstitial lung disease (ILD) who are shown after pathological examination not to have this disease. All tissue and blood specimens and clinical data will be banked and stored for distribution to future investigators who have approved study proposals and are investigating the pathogenesis of the aforementioned lung diseases.