Formulation of a pan-species, multi-stage vaccine for the malaria eradication agenda

为根除疟疾议程制定泛物种、多阶段疫苗

• 批准号: nhmrc : GNT1093311
• 负责人: Prof Daniel Schofield
• 金额: $ 75.54万
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/formulation-pan-species-eradication-agenda/1345913
• 关键词: Formulation; pan; species; multi; stage

GNT 1093311 entitled 'Formulation of a pan-species, multi-stage vaccine for the malaria eradication agenda' seeks to undertake the preclinical development of a saccharide conjugate vaccine directed towards all major species and stages of malaria. The objectives are: (i) to undertake the synthesis of the vaccine construct; (ii) to compare immunogenicity, formulation and efficacy of various vaccine constructs with a view to down-selecting the optimal combination to take to human clinical trial.

GNT 1093311题为“制定用于疟疾根除议程的泛物种、多阶段疫苗”，旨在进行针对疟疾所有主要物种和阶段的糖缀合物疫苗的临床前开发。目标是：（i）进行疫苗构建体的合成;（ii）比较各种疫苗构建体的免疫原性、制剂和功效，以向下选择最佳组合用于人类临床试验。