Formulation of a pan-species, multi-stage vaccine for the malaria eradication agenda

为根除疟疾议程制定泛物种、多阶段疫苗

• 批准号: nhmrc : 1093311
• 负责人: Prof Daniel Schofield
• 金额: $ 51.85万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/formulation-pan-species-eradication-agenda/519425
• 关键词: Formulation; pan; species; multi; stage

GNT 1093311 entitled 'Formulation of a pan-species, multi-stage vaccine for the malaria eradication agenda' seeks to undertake the preclinical development of a saccharide conjugate vaccine directed towards all major species and stages of malaria. The objectives are: (i) to undertake the synthesis of the vaccine construct; (ii) to compare immunogenicity, formulation and efficacy of various vaccine constructs with a view to down-selecting the optimal combination to take to human clinical trial.

题为“为消灭疟疾议程研制一种泛物种、多阶段疫苗”的GNT 1093311寻求进行针对所有主要疟疾物种和阶段的糖结合疫苗的临床前研制。目标是：(i)进行疫苗结构的合成；（ii）比较不同疫苗结构的免疫原性、配方和功效，以便从中选择最佳组合进行人体临床试验。