Disparities in CHD in the Jackson Heart Study

杰克逊心脏研究中冠心病的差异

• 批准号: 7100481
• 负责人: MARIO SIMS
• 金额: $ 12.13万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7100481
• 关键词: African American; cardiovascular disorder risk; clinical research; coronary disorder; education; health disparity; health services research tag; human data; income; occupations; prejudice; psychological stressor; racial /ethnic difference; social psychology; social support network; socioeconomics

DESCRIPTION (provided by applicant): This K01 award will allow the candidate, Dr. Mario Sims, to gain the skills, knowledge and experience required to become an independent investigator in health disparities research. Using data from the Jackson Heart Study (JHS), Dr. Sims will examine the extent to which neighborhood socioeconomic status (SES) and key psychosocial factors (discrimination, stress, and social support) impact coronary heart disease (CHD) in African Americans in Mississippi. The JHS is the largest epidemiologic, population-based study of cardiovascular disease (CVD) among African Americans, and one of its primary aims - to develop young talented minority investigators in the field of CVD research - will be accomplished through this KO1 award. CHD is the leading cause of CVD mortality in America, and Mississippi has the highest overall CVD mortality rate in the nation. Moreover, the cardiovascular health disparity between African Americans and whites is widening. Mississippi's CHD mortality rate is higher than the U.S. rate. African Americans have higher CHD prevalence and mortality rates than whites, and they also have a higher prevalence of risk factors associated with CHD such as hypertension, diabetes mellitus, and obesity which clearly might influence the higher prevalence of CHD mortality. To achieve his research and career development goals, Dr. Sims will follow a career development plan at the University of Mississippi Medical Center, designed to provide knowledge, skills, and experience in 6 core competencies required to be a successful independent investigator in health disparities research: 1) research excellence in the area of CHD disparities, 2) advanced statistics and study design, 3) research ethics, 4) leadership and management, 5) presentation and teaching, and 6) scientific writing. This will be accomplished through implementation of an individualized learning plan that includes: 1) academic coursework to develop cardiovascular disease disparity research skills; 2) mentorship and consultation with nationally and internationally recognized experts in cardiovascular disease epidemiology and health disparities research; 3) mentorship by faculty sensitive to the unique needs and issues facing minority academic faculty; and 4) innovative research using a multi-dimensional framework for examining how CHD prevalence among African Americans is influence by neighborhood environments, perceived discrimination, stress, and social support. The proposed mentored research has three specific aims: 1) to examine the extent to which neighborhood SES is associated with CHD among African Americans; 2) to determine the degree to which perceived racial discrimination, stress and social support are associated with CHD among African Americans; and 3) to analyze the extent to which the association of neighborhood SES and CHD is mediated by psychosocial factors among African Americans. This is the first study of its kind to examine multiple pathways by which neighborhood SES and key psychosocial factors impact CHD risk in African Americans in Mississippi, a state with the highest CHD rate in the nation. This research will enable health-care providers to adequately serve their patients with CHD knowing that where they live and their exposure to discrimination, stress, and a lack of social support are sequelae to CHD. This research will also show which factors health policy makers need to focus on in order to address and eliminate CHD disparities.

描述（由申请人提供）： 该K 01奖将使候选人马里奥西姆斯博士获得成为健康差异研究独立调查员所需的技能、知识和经验。利用杰克逊心脏研究（JHS）的数据，西姆斯博士将研究社区社会经济地位（SES）和关键心理社会因素（歧视，压力和社会支持）对密西西比非裔美国人冠心病（CHD）的影响程度。JHS是最大的流行病学，以人群为基础的研究心血管疾病（CVD）在非洲裔美国人，其主要目标之一-发展年轻有才华的少数民族研究人员在CVD研究领域-将通过这个KO 1奖完成。冠心病是美国心血管疾病死亡的主要原因，密西西比州的心血管疾病死亡率是全国最高的。此外，非洲裔美国人和白人之间的心血管健康差距正在扩大。密西西比的冠心病死亡率高于美国。非裔美国人的冠心病患病率和死亡率高于白人，他们也有较高的患病率与冠心病相关的危险因素，如高血压，糖尿病和肥胖，这显然可能会影响较高的冠心病死亡率的患病率。为了实现他的研究和职业发展目标，西姆斯博士将遵循密西西比医学中心大学的职业发展计划，旨在提供成为健康差异研究中成功的独立调查员所需的6项核心能力的知识，技能和经验：1）CHD差异领域的卓越研究，2）先进的统计和研究设计，3）研究道德，4）领导和管理，5）演示和教学，以及6）科学写作。这将通过实施个性化的学习计划来实现，其中包括：1）学术课程，以发展心血管疾病差异研究技能; 2）与国内和国际公认的心血管疾病流行病学和健康差异研究专家进行指导和咨询; 3）对少数民族学术教师面临的独特需求和问题敏感的教师进行指导;和4）创新性研究，使用多维框架来检查非裔美国人中CHD患病率如何受到邻里环境，感知歧视，压力和社会支持的影响。建议的指导研究有三个具体目标：1）检查社区SES与非裔美国人CHD相关的程度; 2）确定感知种族歧视，压力和社会支持与非裔美国人CHD相关的程度; 3）分析社区SES与CHD的关联在多大程度上由非裔美国人的心理社会因素介导。这是同类研究中的第一项研究，旨在研究社区SES和关键心理社会因素影响密西西比非裔美国人CHD风险的多种途径，密西西比州是全国CHD发病率最高的州。这项研究将使卫生保健提供者能够充分为CHD患者提供服务，因为他们知道他们居住的地方以及他们遭受歧视，压力和缺乏社会支持是CHD的后遗症。这项研究还将显示卫生政策制定者需要关注哪些因素，以解决和消除CHD差异。