JACKSON HEART STUDY (JHS) - COORDINATING CENTER (CC) - TO EXERCISE OPTION PERIOD THREE (3) AND REVISE CONTRACT ARTICLES.

杰克逊心脏研究(JHS)始于1998年，是对与非裔美国人心血管疾病(CVD)负担不成比例相关的遗传和环境风险因素进行的纵向调查。此外，JHS还举办了各种社区教育和外展活动，以促进健康的生活方式和减少疾病风险负担。它还开展大学本科生和研究生水平的培训计划以及高中科学和数学充实计划，以准备和鼓励未被充分代表的少数民族学生从事生物医学职业。(www.jacksonHearStudy.org/)。 JHS代表了社区动脉粥样硬化风险研究(ARIC)研究的杰克逊·菲尔德中心(www.cscc.unc.edu/ARIC/)的扩展，以扩大非裔美国人人口的数据收集，并增加非裔美国人人口和科学家对生物医学研究和专业的接触和参与。这项研究招募了5306名非洲裔美国人，其中包括3732名也在ARIC注册的居民，他们生活在密苏里州杰克逊市、Hinds、Madison和Rankin县的大都市区。JHS的注册参与者最初年龄为20-90岁，他们接受了三次背靠背考试(考试1,2000-04；考试2,2005-08；考试3,2009-13)，并每年都会得到联系。截至2016年底，关于身体、行为、遗传和心理社会因素的丰富数据集的研究结果已发表在345多份出版物上。 参与者检查产生了大量关于传统和假定的心血管疾病风险因素、社会经济和社会文化因素以及生化分析的纵向数据；以及通过心脏、主动脉和腹部的超声心动图、心脏磁共振成像(MRI)和计算机断层扫描(CT)对亚临床疾病的测量。已经对储存的生物样本进行了可能的生化风险因素检测，并储存起来以供将来研究。DNA被提取出来，淋巴细胞被冷冻保存，用于候选基因的研究、全基因组扫描、表达和其他组学研究。这项研究包括428个家庭的嵌套部分，在基线时，平均家庭规模为5个；今天，至少有1名在世成员的331个家庭仍在积极参与。幸存队列的参与率很高：分别在两次后续检查中分别有80%(N=4205)和72%(N=3820)。如今，这群人的平均年龄是68岁。自基线以来，还每12个月联系一次队列成员，以获取有关生命状态、当前居住地、重大疾病或伤害以及接触者之间住院情况的信息，以确定感兴趣的突发临床心血管事件。由于JHS与ARIC共享队列成员，这两项研究在事件验证方面相互合作。

The Jackson Heart Study (JHS), initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addition, the JHS performs a variety of community education and outreach activities to promote healthy lifestyles and reduce disease risk burden. It also conducts college undergraduate and graduate-level training programs and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. (www.jacksonheartstudy.org/). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (www2.cscc.unc.edu/aric/), to broaden data collection in an African- American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The study recruited 5306 African-American residents, including 3,732 residents also enrolled in ARIC, living in the Jackson, MS, metropolitan area of Hinds, Madison, and Rankin Counties. Enrolled JHS participants, initially aged 20 - 90 years, received three back-to-back examinations (Exam 1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) and have been contacted annually. Findings on the rich set of data on physical, behavioral, genetic, and psychosocial factors have been presented in over 345 publications as of the end of 2016. Participant exams have produced extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors, and biochemical analytes; and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. The study included a nested component of 428 families with mean family size of 5 at baseline; today 331 families with at least 1 living member still actively participate. Participation of the surviving cohort has been high: 80% (N=4205) and 72% (N=3820) at each of the two respective follow-up examinations. Today the average cohort age is 68 years. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify incident clinical CVD events of interest. Due to JHS’ shared cohort membership with ARIC, the two studies cooperate with each other on events validation.