JACKSON HEART STUDY (JHS) - COORDINATING CENTER (CC) - TO EXERCISE OPTION PERIOD THREE (3) AND REVISE CONTRACT ARTICLES.

杰克逊心脏研究 (JHS) - 协调中心 (CC) - 行使选择权第三 (3) 期并修改合同条款。

• 批准号: 10683919
• 负责人: MARIO SIMS
• 金额: $ 207.13万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-13 至 2023-08-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10683919
• 关键词: Abdomen; Address; African American; African American population; Age; Aorta; Area; Atherosclerosis Risk in Communities; Back; Behavioral Genetics; Biochemical; Biological; Biological Assay; Biomedical Research; Candidate Disease Gene; Cardiovascular Diseases; Cardiovascular system; Clinic; Clinical; Collaborations; Communities; Community Health Education; Contracts; County; Cryopreservation; DNA; Data; Data Collection; Data Set; Development; Disease; Echocardiography; Education and Outreach; Educational Status; Enrollment; Environmental Risk Factor; Event; Exercise; Family; Family Sizes; Fostering; Genetic Risk; Genome Scan; Goals; Heart failure; Hospitalization; Impaired cognition; Injury; Investigation; Jackson Heart Study; Lymphocyte; Mathematics; Measures; Participant; Psychosocial Factor; Publications; Resources; Risk Factors; Sampling; Science; Scientist; Subgroup; Testing; Training Programs; Validation; Ventricular Dysfunction; Vital Status; X-Ray Computed Tomography; aged; biomedical profession; cardiac magnetic resonance imaging; cardiovascular disorder risk; cardiovascular health; career; cognitive function; cohort; college; community living; disorder risk; epidemiology study; follow-up; healthy lifestyle; heart imaging; high school; improved; interest; member; metropolitan; novel; programs; recruit; residence; risk prediction; social culture; socioeconomics; undergraduate student; underrepresented minority student

The Jackson Heart Study (JHS), initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addition, the JHS performs a variety of community education and outreach activities to promote healthy lifestyles and reduce disease risk burden. It also conducts college undergraduate and graduate-level training programs and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. (www.jacksonheartstudy.org/). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (www2.cscc.unc.edu/aric/), to broaden data collection in an African- American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The study recruited 5306 African-American residents, including 3,732 residents also enrolled in ARIC, living in the Jackson, MS, metropolitan area of Hinds, Madison, and Rankin Counties. Enrolled JHS participants, initially aged 20 - 90 years, received three back-to-back examinations (Exam 1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) and have been contacted annually. Findings on the rich set of data on physical, behavioral, genetic, and psychosocial factors have been presented in over 345 publications as of the end of 2016. Participant exams have produced extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors, and biochemical analytes; and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. The study included a nested component of 428 families with mean family size of 5 at baseline; today 331 families with at least 1 living member still actively participate. Participation of the surviving cohort has been high: 80% (N=4205) and 72% (N=3820) at each of the two respective follow-up examinations. Today the average cohort age is 68 years. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify incident clinical CVD events of interest. Due to JHS’ shared cohort membership with ARIC, the two studies cooperate with each other on events validation.

杰克逊心脏研究（JHS）于1998年启动，是一项与非洲裔美国人心血管疾病（CVD）负担不成比例相关的遗传和环境风险因素的纵向调查。 此外，JHS执行各种社区教育和外展活动，以促进健康的生活方式和减少疾病风险负担。 它还开展大学本科和研究生水平的培训计划以及高中科学和数学充实计划，以准备和鼓励代表性不足的少数民族学生从事生物医学职业。（www.jacksonheartstudy.org/）。 JHS是社区动脉粥样硬化风险研究（ARIC）杰克逊现场中心的扩展（www2.cscc.unc.edu/aric/），以扩大非裔美国人的数据收集，并增加非裔美国人和科学家在生物医学研究和专业中的接触和参与。 这项研究招募了5306名非洲裔美国居民，其中包括3,732名也参加了ARIC的居民，他们居住在杰克逊、MS、Hinds、麦迪逊和兰金县的大都市区。 登记的JHS参与者，最初年龄在20 - 90岁之间，接受了三次背靠背的考试（考试1，2000-04;考试2，2005-08;和考试3，2009-13），并每年联系一次。截至2016年底，关于身体、行为、遗传和心理社会因素的丰富数据集的研究结果已发表在超过345篇出版物中。 参与者检查产生了关于传统和推定的CVD风险因素、社会经济和社会文化因素以及生化分析物的广泛纵向数据;以及超声心动图、心脏磁共振成像（MRI）和心脏、主动脉和腹部计算机断层扫描（CT）的亚临床疾病测量。储存的生物样品已被测定推定的生化风险因素，并储存用于未来的研究。提取DNA并冷冻保存淋巴细胞用于候选基因的研究、全基因组扫描、表达和其他组学研究。 该研究包括428个家庭的嵌套组成部分，基线时平均家庭规模为5人;今天有331个家庭至少有1名活着的成员仍然积极参与。 存活队列的参与率很高：两次随访检查分别为80%（N=4205）和72%（N=3820）。今天，平均年龄为68岁。自基线起，还每12个月联系一次队列成员，以获得有关生命状态、当前居住地、重大疾病或损伤以及联系人之间发生的住院情况的信息，以确定关注的偶发临床CVD事件。由于JHS与ARIC共享队列成员资格，这两项研究在事件验证方面相互合作。