Defining the impact of androgens on uterine immune cell function during endometrial tissue repair

确定子宫内膜组织修复过程中雄激素对子宫免疫细胞功能的影响

• 批准号: 2744296
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2744296
• 关键词: Defining; impact; androgens; uterine; immune

The endometrium must repair following menstruation to ensure healthy reproductive function. Endometrial repair requires coordinated action of both hormonal and inflammatory cues and imbalance of these signals is associated with reproductive health disorders. Androgens disrupt repair processes and are unbalanced in a number of disease contexts. Their impact on uterine immune cells populations is poorly understood. This project will investigate the impact of androgens on uterine immune cell function during endometrial repair. This will be assessed by performing phenotypic and transcriptomic characterisation of uterine immune cells using a mouse model of endometrial repair combined with genetic and pharmacologic manipulation of androgen signalling. These insights will be supported by translational studies assessing expression of phenotypic markers of immune dysfunction identified by mouse studies in human endometrial tissues. Collectively, these studies will provide unique insights into the mechanisms that contribute to dysregulated endometrial repair and provide new opportunities for future therapeutic targeting.

月经后子宫内膜必须修复，以确保健康的生殖功能。子宫内膜修复需要激素和炎症信号的协调作用，而这些信号的不平衡与生殖健康障碍有关。雄激素扰乱修复过程，并在许多疾病背景下失衡。它们对子宫免疫细胞种群的影响知之甚少。本项目将研究雄激素在子宫内膜修复过程中对子宫免疫细胞功能的影响。这将通过使用子宫内膜修复的小鼠模型结合雄激素信号的遗传和药物操作来对子宫免疫细胞的表型和转录特征进行评估。这些洞察力将得到翻译研究的支持，该研究评估了小鼠研究确定的免疫功能障碍的表型标记物在人类子宫内膜组织中的表达。总而言之，这些研究将为促进子宫内膜修复失调的机制提供独特的见解，并为未来的治疗靶向提供新的机会。