Investigating the impact of physical activity in modulating PCOS risk among peripubertal females

调查体力活动对调节青春期前后女性 PCOS 风险的影响

• 批准号: 10591971
• 负责人: Rachel Whooten
• 金额: $ 19.42万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591971
• 关键词: Adolescence; Adolescent; Adult; Advisory Committees; Affect; Age; Androgens; Area; Attenuated; Behavior; Behavior Therapy; Behavioral; Biometry; Cardiovascular Diseases; Caregivers; Childhood; Chronic Disease; Clinical; Clinical Trials Design; Collection; Communities; Complex; Data; Development; Diabetes Mellitus; Dissemination and Implementation; Endocrine; Endocrine Physiology; Endocrinologist; Enrollment; Epidemiology; Female; Female Adolescents; Focus Groups; Functional disorder; Goals; Health; Health Care Costs; Health Services; Health behavior; Hormones; Hyperandrogenemia; Infertility; Insulin; Insulin Resistance; Intervention; Irregular Menstruation; K-Series Research Career Programs; Knowledge; Lead; Life Cycle Stages; Literature; Longitudinal cohort; Measurement; Measures; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentorship; Metabolic; Metabolic Diseases; Methods; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Obesity; Outcome; Phenotype; Physical activity; Physiological; Polycystic Ovary Syndrome; Prevention; Prevention strategy; Primary Prevention; Process; Public Health; Randomized; Reproductive Health; Research; Research Personnel; Research Priority; Risk; Series; Strenuous Exercise; Structure; Target Populations; Teenagers; Time; Training; Treatment Efficacy; Woman; Work; actigraphy; career; cohort; comorbidity; critical period; design; disorder prevention; early adolescence; effective intervention; efficacy trial; evidence base; exercise intervention; feasibility testing; follow-up; girls; implementation intervention; implementation science; improved; insight; insulin sensitivity; intervention participants; longitudinal analysis; metabolomics; multidisciplinary; obesity prevention; pilot trial; preventive intervention; reproductive; skills; therapy design; tool; young woman

PROJECT ABSTRACT Polycystic Ovary Syndrome (PCOS) affects 1 out of 10 women worldwide. While PCOS is primarily characterized by menstrual irregularity and hyperandrogenemia, it is also associated with multiple comorbidities – including diabetes, cardiovascular disease, depression, and infertility – that lead to substantial morbidity and health care costs. A complex interaction between adiposity, decreased insulin sensitivity, and increased androgen concentrations underlies the pathophysiology of PCOS. These signs often first appear in early adolescence, representing a key opportunity for preventive interventions. While physical activity is a promising strategy for targeting the factors underlying PCOS development, there is a significant literature gap regarding effective strategies for use in PCOS prevention. The goal of this proposal is to identify the time course of changes in insulin dynamics and androgen concentrations in females from mid-childhood through adolescence and the impact of physical activity during early adolescence on these endpoints (Aim 1) and use implementation science methods to refine (Aim 2) and pilot a targeted and evidence-based physical activity intervention in peripubertal girls ages 8-10 at risk for PCOS while assessing the interventions’ feasibility, acceptability, and preliminary efficacy in relation to physical activity levels, insulin sensitivity, and androgen concentrations (Aim 3). The findings from this study will inform the development, dissemination, and implementation of effective and scalable preventive interventions, a high priority area for the NIDDK. Additionally, by specifically targeting young females at risk for later metabolic disease, this proposal takes a life-course approach to chronic disease prevention. The PI, Dr. Whooten, is an early career clinician investigator and pediatric endocrinologist, as well as health services researcher. She will use this career development award to build her skills in (1) the longitudinal analysis of epidemiological cohorts, (2) design and implementation of behavioral interventions informed by an implementation science approach, and (3) collection and measurement of objective behavioral and physiologic outcomes which will be essential for evaluating intervention efficacy. Dr. Whooten will work closely with a multidisciplinary mentorship and advisory team with expertise in epidemiology, objective measurement of health behaviors, measurement of endocrine physiologic outcomes, implementation science, and biostatistics to carry out her stated career objectives and specific aims.

项目摘要