Development of viscerosensory neural inputs in rat brain

大鼠大脑内脏感觉神经输入的发展

• 批准号: 7113327
• 负责人: Thomas J Koehnle
• 金额: $ 4.88万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113327
• 关键词: axon; behavior test; behavioral /social science research tag; brain stem; developmental genetics; developmental neurobiology; early experience; emotions; fos protein; hypothalamic pituitary adrenal axis; juvenile animal; laboratory rat; learning; lithium; mother deprivation; motivation; neural information processing; neurogenesis; newborn animals; postdoctoral investigator; psychological stressor; psychopharmacology; psychotropic drugs

DESCRIPTION (provided by applicant): Sensory signals from within the body modulate the physiological and behavioral responses of animals to their environments. Though these interoceptive signals often do not reach conscious awareness, they can have a powerful impact on the motivation and emotional learning of animals placed in different environmental contexts. However, the insights gained so far into the operation of these pathways stem mainly from observation and manipulation of adults, and cannot be generalized to developing animals. The natural process of neural development offers special opportunities to probe the functional organization of interoceptive pathways. The proposed research will address the postnatal ontogeny of central neural pathways that link interoceptive components of the brainstem, hypothalamus, and limbic forebrain in normal and pathological conditions. The proposed research will directly examine functional relationships among interoceptive pathways during normal and abnormal development, filling a major gap in the present literature. The experimental outcomes will significantly enhance our understanding of how these pathways mature, and how they operate in health and disease.

描述（由申请人提供）：体内的感觉信号调节动物对环境的生理和行为反应。尽管这些互感的信号通常无法达到有意识的意识，但它们可能会对位于不同环境环境中的动物的动机和情感学习产生强大的影响。但是，这些途径运行的洞察力主要源于对成年人的观察和操纵，不能推广到发展动物。神经发育的自然过程为探究互感途径的功能组织提供了特殊的机会。拟议的研究将解决中央神经途径的产后个体发育，这些途径将脑干，下丘脑和边缘前脑的互感成分联系起来。拟议的研究将直接检查正常和异常发育期间感知途径之间的功能关系，从而填补了本文的主要空白。实验结果将显着增强我们对这些途径如何成熟以及它们在健康和疾病中的运作方式的理解。