Fractures and bisphosphonates: reviving osteoporosis treatment uptake by identifying the genetic, material, and microstructural risk factors of atypical femur fractures.

骨折和双磷酸盐：通过识别非典型股骨骨折的遗传、物质和微观结构危险因素，恢复骨质疏松症治疗的采用。

• 批准号: nhmrc : 1143364
• 负责人: A/Pr Roderick Clifton-Bligh
• 金额: $ 71.2万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/fractures-bisphosphonates-reviving-femur-fractures/1319932
• 关键词: Fractures; bisphosphonates; reviving; osteoporosis; treatment

Atypical femoral fractures (AFF) are uncommon, but catastrophic, complications of antiresorptive osteoporosis treatments including bisphosphonates. We will identify patients at risk of AFF by determining changes in their bone structure and quality, and identifying genes that increase the risk of these fractures. In this way, cheap and effective antiresorptive treatments can be targeted to patients at the lowest risk of AFF and alternative treatments to those at highest risk.

非典型股骨骨折(AFF)是包括双磷酸盐在内的抗吸收骨质疏松症治疗的罕见但灾难性的并发症。我们将通过确定患者骨骼结构和质量的变化，并确定增加这些骨折风险的基因来确定有AFF风险的患者。通过这种方式，廉价有效的抗吸收治疗可以针对AFF风险最低的患者，而替代治疗可以针对风险最高的患者。