Biomechanics and the lamprey central pattern generator

生物力学和七鳃鳗中心模式发生器

• 批准号: 7053977
• 负责人: ERIC D TYTELL
• 金额: $ 4.4万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7053977
• 关键词: Agnatha; behavioral /social science research tag; biomechanics; brain regulatory center; diving /swimming; electromyography; environmental adaptation; mathematical model; model design /development; neural information processing; neuromuscular function; neurophysiology; postdoctoral investigator; psychomotor function; sensory feedback; videotape /videodisc

DESCRIPTION (provided by applicant): The primary goal of this proposal is to examine how the environment and the body's mechanical properties couple with an organism's neural architecture to produce an adaptive behavior. The importance of sensory feedback and direct mechanical coupling between the body and environment will be investigated using lamprey swimming as a paradigm for vertebrate motor behavior. Lampreys cannot produce an effective swimming behavior without these interactions, but the details of how coupling and feedback modulate the spinal central pattern generators (CPGs) to produce the behavior, is unknown. The interaction will be examined at three levels: the influence of sensory input on the isolated spinal cord, the feedback loop between the CPGs and the axial musculature, and the mechanical coupling between the muscles and the fluid environment. A mathematical model of the CPG will be constructed to aid in interpretation and generalization of the results to vertebrate locomotion as a whole. This combination of mathematical modeling and experimental tests of different levels of the interaction will allow a broad evaluation of how the vertebrate central nervous system acts together with the body and environment to produce a motor behavior.

描述（由申请人提供）：本提案的主要目标是研究环境和身体的机械特性如何与生物体的神经结构耦合以产生适应性行为。本研究将以七鳃鳗游泳作为脊椎动物运动行为的范例，探讨感官回馈与身体与环境间直接机械耦合的重要性。七鳃鳗不能产生一个有效的游泳行为没有这些相互作用，但耦合和反馈如何调制脊髓中央模式发生器（CPG）产生的行为的细节，是未知的。相互作用将在三个层面上进行检查：感觉输入对孤立的脊髓，CPGs和轴向肌肉组织之间的反馈回路的影响，以及肌肉和流体环境之间的机械耦合。一个数学模型的CPG将被构建，以帮助解释和概括的结果，脊椎动物运动作为一个整体。这种数学建模和实验测试的不同层次的相互作用的组合将允许脊椎动物中枢神经系统如何与身体和环境一起产生运动行为的广泛评估。