Biomechanics and the lamprey central pattern generator

生物力学和七鳃鳗中心模式发生器

• 批准号: 7340435
• 负责人: ERIC D TYTELL
• 金额: $ 4.88万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7340435
• 关键词: Acceleration; Accounting; Adaptive Behaviors; Architecture; Beer; Behavior; Biomechanics; Complex; Condition; Coupling; Data; Decompression Sickness; Dictyoptera; Environment; Evaluation; Experimental Models; Feedback; Felis catus; Fellowship; Frequencies; Friction; Goals; In Vitro; Individual; Invertebrates; Lampreys; Liquid substance; Locomotion; Measures; Mechanics; Motion; Motor; Motor Neurons; Muscle; Names; Neuraxis; Organism; Output; Phase; Play; Preparation; Property; Reaction; Relative (related person); Role; Role playing therapy; Rome; Sensory; Spinal; Spinal Cord; Stimulus; Structure; Swimming; Tail; Testing; Time; Vertebrates; Viscosity; Water; Weight; body mechanics; central pattern generator; insight; kinematics; mathematical model; pressure; relating to nervous system; research study; sensory feedback

The primary goal of this proposal is to examine how the environment and the body's mechanical properties couple with an organism's neural architecture to produce an adaptive behavior. The importance of sensory feedback and direct mechanical coupling between the body and environment will be investigated using lamprey swimming as a paradigm for vertebrate motor behavior. Lampreys cannot produce an effective swimming behavior without these interactions, but the details of how coupling and feedback modulate the spinal central pattern generators (CPGs) to produce the behavior is unknown. The interaction will be examined at three levels: the influence of sensory input on the isolated spinal cord, the feedback loop between the CPGs and the axial musculature, and the mechanical coupling between the muscles and the fluid environment. A mathematical model of the CPG will be constructed to aid in interpretation and generalization of the results to vertebrate locomotion as a whole. This combination of mathematical modeling and experimental tests of different levels of the interaction will allow a broad evaluation of how the vertebrate central nervous system acts together with the body and environment to produce a motor behavior.

该提案的主要目标是检查环境和人体的机械特性如何 夫妇与生物体的神经结构产生适应性行为。感官的重要性 将研究身体和环境之间的反馈和直接机械耦合 七lamp虫游泳是脊椎动物运动行为的范式。七lamp子无法产生有效的 没有这些相互作用的游泳行为，但是耦合和反馈如何调节的细节 产生行为的脊柱中央模式发生器（CPG）尚不清楚。互动将是 在三个级别检查：感觉输入对孤立的脊髓的影响，反馈回路 在CPG和轴向肌肉组织之间，以及肌肉和肌肉之间的机械耦合 流体环境。将构建CPG的数学模型，以帮助解释和 整个脊椎动物运动的概括。这种数学的结合 对不同水平的建模和实验测试将允许对如何进行广泛评估 脊椎动物中枢神经系统与身体和环境一起起作用，产生运动行为。

项目成果

Disentangling the functional roles of morphology and motion in the swimming of fish.

• DOI: 10.1093/icb/icq057
• 发表时间: 2010-12
• 期刊: Integrative and comparative biology
• 影响因子: 2.6
• 作者: E. Tytell;I. Borazjani;F. Sotiropoulos;T. Baker;E. Anderson;G. Lauder

Hydrodynamics of the escape response in bluegill sunfish, Lepomis macrochirus.

• DOI: 10.1242/jeb.020917
• 发表时间: 2008-11
• 期刊: The Journal of experimental biology
• 作者: Tytell ED;Lauder GV
• 通讯作者: Lauder GV