Biomechanics and the lamprey central pattern generator

生物力学和七鳃鳗中心模式发生器

• 批准号: 7340435
• 负责人: ERIC D TYTELL
• 金额: $ 4.88万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7340435
• 关键词: Acceleration; Accounting; Adaptive Behaviors; Architecture; Beer; Behavior; Biomechanics; Complex; Condition; Coupling; Data; Decompression Sickness; Dictyoptera; Environment; Evaluation; Experimental Models; Feedback; Felis catus; Fellowship; Frequencies; Friction; Goals; In Vitro; Individual; Invertebrates; Lampreys; Liquid substance; Locomotion; Measures; Mechanics; Motion; Motor; Motor Neurons; Muscle; Names; Neuraxis; Organism; Output; Phase; Play; Preparation; Property; Reaction; Relative (related person); Role; Role playing therapy; Rome; Sensory; Spinal; Spinal Cord; Stimulus; Structure; Swimming; Tail; Testing; Time; Vertebrates; Viscosity; Water; Weight; body mechanics; central pattern generator; insight; kinematics; mathematical model; pressure; relating to nervous system; research study; sensory feedback

The primary goal of this proposal is to examine how the environment and the body's mechanical properties couple with an organism's neural architecture to produce an adaptive behavior. The importance of sensory feedback and direct mechanical coupling between the body and environment will be investigated using lamprey swimming as a paradigm for vertebrate motor behavior. Lampreys cannot produce an effective swimming behavior without these interactions, but the details of how coupling and feedback modulate the spinal central pattern generators (CPGs) to produce the behavior is unknown. The interaction will be examined at three levels: the influence of sensory input on the isolated spinal cord, the feedback loop between the CPGs and the axial musculature, and the mechanical coupling between the muscles and the fluid environment. A mathematical model of the CPG will be constructed to aid in interpretation and generalization of the results to vertebrate locomotion as a whole. This combination of mathematical modeling and experimental tests of different levels of the interaction will allow a broad evaluation of how the vertebrate central nervous system acts together with the body and environment to produce a motor behavior.

这项提案的主要目标是研究环境和人体的机械性能如何影响 与有机体的神经结构结合产生适应性行为。感官的重要性 反馈和直接机械耦合之间的身体和环境将研究使用 七鳃鳗游泳作为脊椎动物运动行为的范例。七鳃鳗不能产生有效的 游泳行为没有这些相互作用，但如何耦合和反馈调节的细节， 脊髓中央模式发生器（CPG）产生的行为是未知的。互动将是 在三个层面上进行了检查：感觉输入对孤立脊髓的影响，反馈回路 之间的CPG和轴向肌肉组织，和肌肉和之间的机械耦合， 流体环境将构建CPG的数学模型以帮助解释， 将结果推广到整个脊椎动物运动。这种数学的结合 不同层次的相互作用的建模和实验测试将允许对 脊椎动物的中枢神经系统与身体和环境共同作用，产生运动行为。

项目成果

Disentangling the functional roles of morphology and motion in the swimming of fish.

• DOI: 10.1093/icb/icq057
• 发表时间: 2010-12
• 期刊: Integrative and comparative biology
• 影响因子: 2.6
• 作者: E. Tytell;I. Borazjani;F. Sotiropoulos;T. Baker;E. Anderson;G. Lauder

Hydrodynamics of the escape response in bluegill sunfish, Lepomis macrochirus.

• DOI: 10.1242/jeb.020917
• 发表时间: 2008-11
• 期刊: The Journal of experimental biology
• 作者: Tytell ED;Lauder GV
• 通讯作者: Lauder GV