Biomechanics and the lamprey central pattern generator

这项建议的主要目标是检查环境和身体的机械性能 与生物体的神经结构相结合，产生适应性行为。感官的重要性 身体和环境之间的反馈和直接机械耦合将使用以下方法进行研究 七鳃鳗游泳作为脊椎动物运动行为的范例。七鳃鳗不能产生有效的 没有这些相互作用的游泳行为，但耦合和反馈如何调节 脊髓中枢模式发生器(CPGs)产生这种行为的机制尚不清楚。互动将是 从三个层面进行检查：感觉输入对分离的脊髓、反馈回路的影响 在CPG和轴向肌肉系统之间，以及肌肉和 流动的环境。将建立中央人民政府的数学模型，以帮助解释和 将结果推广到整个脊椎动物的运动。这种数学上的组合 对不同级别的交互进行建模和实验测试将允许广泛评估 脊椎动物的中枢神经系统与身体和环境共同作用，产生运动行为。

The primary goal of this proposal is to examine how the environment and the body's mechanical properties couple with an organism's neural architecture to produce an adaptive behavior. The importance of sensory feedback and direct mechanical coupling between the body and environment will be investigated using lamprey swimming as a paradigm for vertebrate motor behavior. Lampreys cannot produce an effective swimming behavior without these interactions, but the details of how coupling and feedback modulate the spinal central pattern generators (CPGs) to produce the behavior is unknown. The interaction will be examined at three levels: the influence of sensory input on the isolated spinal cord, the feedback loop between the CPGs and the axial musculature, and the mechanical coupling between the muscles and the fluid environment. A mathematical model of the CPG will be constructed to aid in interpretation and generalization of the results to vertebrate locomotion as a whole. This combination of mathematical modeling and experimental tests of different levels of the interaction will allow a broad evaluation of how the vertebrate central nervous system acts together with the body and environment to produce a motor behavior.