Fractures and bisphosphonates: reviving osteoporosis treatment uptake by identifying the genetic, material, and microstructural risk factors of atypical femur fractures.

骨折和双磷酸盐：通过识别非典型股骨骨折的遗传、物质和微观结构危险因素，恢复骨质疏松症治疗的采用。

• 批准号: nhmrc : GNT1143364
• 负责人: A/Pr M Zillikens
• 金额: $ 105.31万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/fractures-bisphosphonates-reviving-femur-fractures/1348522
• 关键词: Fractures; bisphosphonates; reviving; osteoporosis; treatment

Atypical femoral fractures (AFF) are uncommon, but catastrophic, complications of antiresorptive osteoporosis treatments including bisphosphonates. We will identify patients at risk of AFF by determining changes in their bone structure and quality, and identifying genes that increase the risk of these fractures. In this way, cheap and effective antiresorptive treatments can be targeted to patients at the lowest risk of AFF and alternative treatments to those at highest risk.

非典型股骨骨折（AFF）并不常见，但却是包括双磷酸盐在内的抗吸收性骨质疏松症治疗的灾难性并发症。我们将通过确定患者骨骼结构和质量的变化以及识别增加这些骨折风险的基因来识别有 AFF 风险的患者。通过这种方式，可以针对 AFF 风险最低的患者提供廉价而有效的抗骨吸收治疗，并为风险最高的患者提供替代治疗。