Copper Complexes with Antibacterial Activity

具有抗菌活性的铜配合物

• 批准号: 2744812
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2744812
• 关键词: Copper; Complexes; Antibacterial; Activity

Antibiotic resistance is a major issue worldwide, leading to many deaths, particularly in developing countries. An enzyme family, the metallo-beta-carbapenemases, have recently been identified as a an important target to overcome antibiotic resistance. Copper complexes are effective at inhibiting this enzyme through transmetallation. In this PhD project, we will design, synthesise and analyse series of copper pyrithione complexes, which are proposed to be effective inhibitors of the carbapenemase enzymes. We will develop structure to activity relationships and identify important properties of the complexes, such as solubility, lipophilicity, bacterial cell uptake and biological activity against the resistant bacteria. The project combines synthetic chemistry with aspects of biochemistry. Our collaborators in India will be involved with the bacterial testing against antibiotic resistant bacteria.

抗生素耐药性是全球一个主要问题，导致许多死亡，尤其是在发展中国家。最近已将酶家族（金属β-核糖酶）确定为克服抗生素耐药性的重要靶标。铜配合物可有效通过转基因抑制这种酶。在这个博士学位项目中，我们将设计，合成和分析系列铜吡啶家复合物，这些复合物被认为是碳青霉酶酶的有效抑制剂。我们将发展为活性关系的结构，并确定复合物的重要特性，例如溶解度，亲脂性，细菌细胞摄取和对抗性细菌的生物学活性。该项目将合成化学与生物化学方面相结合。我们在印度的合作者将参与针对抗生素耐药细菌的细菌测试。