Control of Chemokine Production by Memory T Cells
Control of Chemokine Production by Memory T Cells
批准号:
7096571
负责人:
Philippa C. Marrack
金额:
$26.18万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-08-01 至 2008-07-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION (provided by applicant): Memory T cells contain large amounts of mRNA for certain chemokines, including RANTES, MIP-1alpha and MIP-1beta. This mRNA is not translated, however, unless the cells are stimulated via their T cell receptors. Experiments will be performed to find out what portion of the chemokine mRNAs is involved in the silencing and which signaling pathways induced by T cell receptor engagement release the mRNAs from translational inhibition.
Memory T cells may use these stores of preformed chemokine mRNA for very rapid responses to antigen. A protocol will be established to find out whether this is so, in animals.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Administrative Core
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批准号:8311797
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项目类别:
-
资助金额:$7.6万
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财政年份:2011
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负责人:Philippa C. Marrack
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依托单位:
Functions of Bcl-2 Related Proteins in Activated T Cell Death
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批准号:8311793
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项目类别:
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资助金额:$24.97万
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财政年份:2011
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负责人:Philippa C. Marrack
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依托单位:
Antigen Recognition by Lymphocytes
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批准号:7846521
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项目类别:
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资助金额:$2.13万
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财政年份:2009
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负责人:Philippa C. Marrack
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依托单位:
Administrative Core
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批准号:7694126
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项目类别:
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资助金额:$6.41万
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财政年份:2008
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负责人:Philippa C. Marrack
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依托单位:
Functions of Bcl-2 Related Proteins in Activated T Cell Death
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批准号:7663282
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项目类别:
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资助金额:$24.6万
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财政年份:2008
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负责人:Philippa C. Marrack
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依托单位:
Administrative
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批准号:7188255
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项目类别:
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资助金额:$7.64万
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财政年份:2007
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负责人:Philippa C. Marrack
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依托单位:
Functions of Bcl-2 Related Proteins in Activated T Cell Death
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批准号:7188251
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项目类别:
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资助金额:$24.13万
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财政年份:2006
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负责人:Philippa C. Marrack
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依托单位:
AMID in Apoptosis and p53-Mediated Downstream Effects
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批准号:7092608
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项目类别:
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资助金额:$27.31万
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财政年份:2004
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负责人:Philippa C. Marrack
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依托单位:
AMID in Apoptosis and p53-Mediated Downstream Effects
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批准号:7227149
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项目类别:
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资助金额:$26.52万
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财政年份:2004
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负责人:Philippa C. Marrack
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依托单位:
AMID in Apoptosis and p53-Mediated Downstream Effects
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批准号:7908140
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项目类别:
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资助金额:$12.48万
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财政年份:2004
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负责人:Philippa C. Marrack
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依托单位:
AMID in Apoptosis and p53-Mediated Downstream Effects
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批准号:7408606
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项目类别:
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资助金额:$26.52万
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财政年份:2004
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负责人:Philippa C. Marrack
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依托单位:
Control of Chemokine Production by Memory T Cells
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批准号:6507910
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项目类别:
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资助金额:$22.81万
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财政年份:2002
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负责人:Philippa C. Marrack
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依托单位:
Control of Chemokine Production by Memory T Cells
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批准号:6610997
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项目类别:
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资助金额:$26.13万
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财政年份:2002
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负责人:Philippa C. Marrack
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依托单位:
Control of Chemokine Production by Memory T Cells
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批准号:6916461
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项目类别:
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资助金额:$26.69万
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财政年份:2002
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负责人:Philippa C. Marrack
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依托单位:
Control of Chemokine Production by Memory T Cells
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批准号:6765903
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项目类别:
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资助金额:$26.57万
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财政年份:2002
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负责人:Philippa C. Marrack
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依托单位:
LIFE AND DEATH OF ANTIGEN ACTIVATED T CELLS IN VIVO
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批准号:6201079
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项目类别:
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资助金额:$16.72万
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财政年份:1999
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负责人:Philippa C. Marrack
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依托单位:
LIFE AND DEATH OF ANTIGEN ACTIVATED T CELLS IN VIVO
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批准号:6099168
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项目类别:
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资助金额:$16.72万
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财政年份:1998
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负责人:Philippa C. Marrack
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依托单位:
LIFE AND DEATH OF ANTIGEN ACTIVATED T CELLS IN VIVO
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批准号:6234683
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项目类别:
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资助金额:$17.74万
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财政年份:1997
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负责人:Philippa C. Marrack
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依托单位:
Antigen Recognition by Lymphocytes
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批准号:7663286
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项目类别:
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资助金额:$130.99万
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财政年份:1997
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负责人:Philippa C. Marrack
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依托单位:
Antigen Recognition by Lymphocytes
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批准号:7929677
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项目类别:
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资助金额:$134.92万
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财政年份:1997
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负责人:Philippa C. Marrack
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依托单位:
海外基金