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Control of Chemokine Production by Memory T Cells

Control of Chemokine Production by Memory T Cells
记忆 T 细胞对趋化因子产生的控制
批准号:
7096571
负责人:
Philippa C. Marrack
金额:
$26.18万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-08-01 至 2008-07-31

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Memory T cells contain large amounts of mRNA for certain chemokines, including RANTES, MIP-1alpha and MIP-1beta. This mRNA is not translated, however, unless the cells are stimulated via their T cell receptors. Experiments will be performed to find out what portion of the chemokine mRNAs is involved in the silencing and which signaling pathways induced by T cell receptor engagement release the mRNAs from translational inhibition. Memory T cells may use these stores of preformed chemokine mRNA for very rapid responses to antigen. A protocol will be established to find out whether this is so, in animals.
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Administrative Core
  • 批准号:
    8311797
  • 项目类别:
  • 资助金额:
    $7.6万
  • 财政年份:
    2011
  • 负责人:
    Philippa C. Marrack
  • 依托单位:
Functions of Bcl-2 Related Proteins in Activated T Cell Death
  • 批准号:
    8311793
  • 项目类别:
  • 资助金额:
    $24.97万
  • 财政年份:
    2011
  • 负责人:
    Philippa C. Marrack
  • 依托单位:
Antigen Recognition by Lymphocytes
  • 批准号:
    7846521
  • 项目类别:
  • 资助金额:
    $2.13万
  • 财政年份:
    2009
  • 负责人:
    Philippa C. Marrack
  • 依托单位:
Administrative Core
  • 批准号:
    7694126
  • 项目类别:
  • 资助金额:
    $6.41万
  • 财政年份:
    2008
  • 负责人:
    Philippa C. Marrack
  • 依托单位:
海外基金