Autonomous Microscale Manufacture of Oral Solid Dosage Forms

口服固体剂型的自主微量生产

• 批准号: 2745755
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2745755
• 关键词: Autonomous; Microscale; Manufacture; Oral; Solid

This project will be part of the Made Smarter Innovation - Digital Medicines Manufacturing Research Centre (DM2) with a focus on creating a unique autonomous microscale drug product manufacturing and testing system to select formulation and process that result in a stable product with desired critical quality attributes (CQAs). The platform will perform fundamental research into resolving the complex, multi-length and -dimensional material-process-product-performance relationship. Integrating industrial digital technologies (IDTs) will de-risk and accelerate drug product manufacture, dramatically reducing development time and raw material/solvents, whilst achieving CQA objectives by self-optimised formulation and process conditions. This will be co-developed with supporting industry partners focussing on 1) tablets (via direct compression) and 2) capsule (via powder fill).

该项目将是Made Smarter Innovation-Digital Medicines制造研究中心(DM2)的一部分，重点是创建一个独特的自主微型药物产品制造和测试系统，以选择能够产生具有所需关键质量属性(CQA)的稳定产品的配方和工艺。该平台将对解决复杂、多长度、多维的材料-工艺-产品-性能关系进行基础研究。集成工业数字技术(IDT)将降低风险并加快药品生产，大大减少开发时间和原材料/溶剂，同时通过自我优化的配方和工艺条件实现CQA目标。这将与支持行业合作伙伴共同开发，专注于1)片剂(通过直接压片)和2)胶囊(通过粉状填充)。