Microscale Radionuclide S-values for αRPT
αRPT 的微量放射性核素 S 值
基本信息
- 批准号:10713711
- 负责人:
- 金额:$ 47.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-19 至 2028-08-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAlpha Particle EmitterAlpha ParticlesAnatomic ModelsAnatomyBeta ParticleBloodBlood capillariesBone MarrowCellsChemoresistanceClinicalClinical TrialsDevelopmentDiseaseDisseminated Malignant NeoplasmDoseFamily suidaeFreezingFutureGenerationsGeometryGoalsHarvestHemorrhageHistologyHumanImageIndividualKidneyKupffer CellsLabelLaboratory miceLacrimal gland structureLibrariesLinear Energy TransferLiverLobeLobuleLungMarrowMethodologyMethodsMicroanatomyMiniature SwineModelingMusNephronsNormal tissue morphologyOrganOrgan ModelPathologyPatientsPhotonsPopulationPre-Clinical ModelPredispositionPublishingRadiation Dose UnitRadiobiologyRadioisotopesRadiopharmaceuticalsRiskRisk AssessmentSalivary GlandsSeriesSinusSiteSmall IntestinesSourceSpecimenStructureSystemic TherapyTestingTimeTissue ModelTissuesToxic effectUncertaintyWorkabsorptioncancer radiation therapycancer therapydigital imagingdosimetryeffective therapyhuman imagingin vivoindividual patientindividualized medicineinterestinterpatient variabilitykidney cortexmicroCTneoplastic cellnovelparticleporcine modelpreservationprogramsradiation resistanceskeletalsoft tissuetargeted treatmentthree-dimensional modelingtissue preparationtooltreatment planningtumorvalidation studies
项目摘要
Abstract / Summary – Project 2
Radiopharmaceuticals labeled with alpha-particle emitters (RPT) uniquely satisfy various conditions for therapy
of cancer in its advanced stages. Alpha particles have high linear-energy transfer (~100 keV / m) and thus short
tissue ranges (~50-80 m). Resultantly, they can sterilize tumor cells with as few as 1-3 particle traversals, in
contrast to the requirement of 1000s of beta-particle traversals. Furthermore, they are not susceptible to
chemoresistance, and are minimally susceptible to radioresistance. In the development of patient-specific
treatment planning for RPT, one primary objective is to ensure that the radiation dose to normal tissues and
organs approaches, but remains below, thresholds for toxicity. Assessment of alpha-particle dosimetry of organs
at potential toxicity risk can be performed via the MIRD schema, but it ideally must be applied at a spatial scale
that is pertinent to the specific cell populations which drive toxicity, and that is relevant to the ranges of the
emitted alpha particles. The MIRD schema states that the absorbed dose to a target region may be computed
as the product of the time-integrated activity in a source region (i.e., total number of radionuclide decays) and
the radionuclide S-value (absorbed dose to the target region per decay in the source region). Traditionally, the
MIRD defines source and target regions as whole organs (liver or kidney) or perhaps organ subregions (e.g.,
liver lobe or renal cortex). Given the ranges of alpha particles, however, source and target regions would ideally
be defined at a more microscale level. The main goal of Project 2 is thus to develop a comprehensive library of
microscale S-values which will support RPT in the following organs: bone marrow, kidneys, liver, lungs, salivary
glands, lacrimal glands, and small intestine. Aim 1 will develop geometric-based models of these tissues in both
the human and mouse; we have previously published such models for both bone marrow and kidneys. In Aim
2, we will develop a new generation of 3D tissue models for microscale S-value computation based upon an
extensive library of high-quality serial histology images of these same tissues. These models (both mouse and
human) will be constructed across multi-ROIs (quantifying intra-organ variability) and multiple individuals
(quantifying inter-patient variability). Prior studies have indicated that the laboratory mouse is not a robust pre-
clinical model for RPT induced marrow toxicity. Consequently, in Aim 3 studies will focus on microscale bone
marrow S-values in the higher-species model of the mini-pig. Also, a microscale model of the porcine kidney will
be developed to allow for inter-species extrapolation. Aim 4 studies will focus on validating our Aim 2 and 3
models with respect to tissue volume changes and potential loss of blood in the tissue capillaries. Understanding
these changes will allow more accurate modeling of their in-vivo state.
摘要/摘要-项目2
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WESLEY E BOLCH其他文献
WESLEY E BOLCH的其他文献
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{{ truncateString('WESLEY E BOLCH', 18)}}的其他基金
Project 1: Deployable Software for the Rapid Assessment of Organ Dose Following Radionuclide Intakes
项目 1:用于快速评估放射性核素摄入后器官剂量的可部署软件
- 批准号:
10327396 - 财政年份:2022
- 资助金额:
$ 47.7万 - 项目类别:
Project 1: Deployable Software for the Rapid Assessment of Organ Dose Following Radionuclide Intakes
项目 1:用于快速评估放射性核素摄入后器官剂量的可部署软件
- 批准号:
10589871 - 财政年份:2022
- 资助金额:
$ 47.7万 - 项目类别:
Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
开发用于血液剂量测定的全身计算模型,以模拟辐射对免疫系统的影响
- 批准号:
10429988 - 财政年份:2020
- 资助金额:
$ 47.7万 - 项目类别:
Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
开发用于血液剂量测定的全身计算模型,以模拟辐射对免疫系统的影响
- 批准号:
10655343 - 财政年份:2020
- 资助金额:
$ 47.7万 - 项目类别:
Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
开发用于血液剂量测定的全身计算模型,以模拟辐射对免疫系统的影响
- 批准号:
10214573 - 财政年份:2020
- 资助金额:
$ 47.7万 - 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
- 批准号:
10200807 - 财政年份:2019
- 资助金额:
$ 47.7万 - 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
- 批准号:
10456116 - 财政年份:2019
- 资助金额:
$ 47.7万 - 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
- 批准号:
10696129 - 财政年份:2019
- 资助金额:
$ 47.7万 - 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
- 批准号:
10017971 - 财政年份:2019
- 资助金额:
$ 47.7万 - 项目类别:
APPLICATION OF MR IMAGING TO THE STUDY OF BONE DOSIMETRY
MR成像在骨剂量研究中的应用
- 批准号:
7182973 - 财政年份:2005
- 资助金额:
$ 47.7万 - 项目类别:
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