PlanUNC Research Platform for Radiotherapy Simulation

PlanUNC 放射治疗模拟研究平台

• 批准号: 7090758
• 负责人: EDWARD L. CHANEY
• 金额: $ 54.78万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7090758
• 关键词: Internet; bioimaging /biomedical imaging; computer human interaction; computer program /software; computer simulation; computer system design /evaluation; health science research support; image guided surgery /therapy; patient care planning; radiation therapy

DESCRIPTION (provided by applicant): The unavoidable dose delivered to nearby radiosensitive structures limits the maximum radiation dose that can be delivered safely to the tumor target during external beam radiation therapy for the treatment of cancer. To reduce the risk of unacceptable morbidity each individual course of radiation therapy must be carefully preplanned to achieve a high tumor dose while sparing normal tissues as much as possible. This guiding principle of radiation therapy dose planning has been refined to the modern concept of dose conformation--shaping the dose distribution to match the target m that pervades most modern research in radiation therapy. Innovative technologies, methods, and ideas for three-dimensional (3-D) and even four-dimensional (3-D + time) image-guided treatment simulation and delivery have pushed this concept at the research level to the extreme limit of essentially shrink-wrapping the high dose region to a conformal glove-like fit around the target volume while enveloping sensitive tissues in protective lower dose regions, even in the context of spatially complex and time-varying geometrical shapes and relationships of the tumor and surrounding normal anatomy. Research in this area is gaining momentum from clinical trials that are producing medical evidence showing highly conformal radiation therapy, both with and without dose escalation, significantly increases the probability of favorable clinical outcome both in terms of improving tumor control and reducing the occurrence of side effects. Graphically sophisticated and analytically complex software tools are essential resources for conducting image guided computer simulations (virtual simulation) and optimizations of treatment delivery, including highly accurate dose calculations. Our overall aim is to fill a national need for a fully documented and supported, open and extensible treatment planning and virtual simulation research platform for investigating new techniques and methods for image-guided radiotherapy treatment simulation and delivery.

描述（由申请人提供）：输送到附近放射敏感结构的不可避免的剂量限制了在用于治疗癌症的外部射束放射治疗期间可以安全输送到肿瘤靶点的最大放射剂量。为了降低不可接受的发病率的风险，每个单独的放射治疗过程必须仔细预先计划，以达到高肿瘤剂量，同时尽可能多地保护正常组织。放射治疗剂量计划的指导原则已经被改进为现代的剂量构造概念--使剂量分布与贯穿放射治疗中的大多数现代研究的目标相匹配。三维（3-D）甚至四维的创新技术、方法和理念（3-D +时间）图像引导的治疗模拟和递送已经在研究水平上将该概念推到了极限，即基本上将高剂量区域收缩包裹成围绕靶体积的适形手套状配合，同时将敏感组织包裹在保护性较低剂量区域中，即使在肿瘤和周围正常解剖结构的空间复杂和时变几何形状和关系的情况下。这一领域的研究正在从临床试验中获得动力，这些临床试验正在产生医学证据，表明高度适形放射治疗，无论是否有剂量递增，都显着增加了在改善肿瘤控制和减少副作用发生方面的有利临床结果的可能性。复杂的图形和分析软件工具是进行图像引导计算机模拟（虚拟模拟）和优化治疗提供（包括高度精确的剂量计算）的重要资源。我们的总体目标是满足国家对充分记录和支持，开放和可扩展的治疗计划和虚拟模拟研究平台的需求，以研究图像引导放射治疗模拟和交付的新技术和方法。