Development of Ultrabright Surface Enhanced Raman Scattering (SERS) Nanotags.

超亮表面增强拉曼散射 (SERS) 纳米标签的开发。

• 批准号: 2746224
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2746224
• 关键词: Development; Ultrabright; Surface; Enhanced; Raman

Surface enhanced Raman scattering (SERS) is an extremely sensitive and selective technique that is rapidly emerging as an effective method for ultrasensitive analysis. It offers an increased enhancement over normal Raman scattering; therefore, it is ideal for the detection of trace amounts of analyte. And because of the molecularly specific spectra obtained it is perfect for detecting analytes in mixtures. Nanotags are optical bright metal nanoparticles that give a strong SERS response and can be used to carry out ultrasensitive detection in, for example, bioanalytical assays for the detection of disease relevant biomarkers. Nanotags can be coded with different SERS active labels to allow very sensitive multiplex detection due to their unique and sharp vibrational spectra.This project proposes to develop and optimise optically bright nanotags to carry out detection using excitation wavelengths at 785 nm and above. This will require synthesising different types of metal nanoparticles which have absorbances towards the infrared region of the electromagnetic nanoparticles and will be stable to the environment in which they will act as a label. This may involve, for example, encapsulation of the nanotags in silica or polymer. We will also use state of the art, advanced analytical techniques to characterise the nanotags and understand their SERS properties at the single particle level.

表面增强拉曼散射（Sers）是一种非常灵敏和选择性的技术，正迅速成为一种有效的超灵敏分析方法。它提供了一个增加的增强超过正常的拉曼散射，因此，它是理想的检测痕量的分析物。由于获得的分子特异性光谱，它非常适合检测混合物中的分析物。纳米标签是光学明亮的金属纳米颗粒，其给出强Sers响应，并且可以用于在例如用于检测疾病相关生物标志物的生物分析测定中进行超灵敏检测。纳米标签可以用不同的Sers活性标记进行编码，由于其独特而尖锐的振动光谱，因此可以进行非常灵敏的多重检测。本项目建议开发和优化光学明亮的纳米标签，以使用785 nm及以上的激发波长进行检测。这将需要合成不同类型的金属纳米颗粒，这些金属纳米颗粒具有朝向电磁纳米颗粒的红外区域的散射，并且对于它们将充当标签的环境是稳定的。这可以涉及例如将纳米标签封装在二氧化硅或聚合物中。我们还将使用最先进的分析技术来分析纳米标签，并在单粒子水平上了解它们的Sers特性。