Deep eutectic solvents as reaction media for chemoenzymatic cascades in continuous flow

低共熔溶剂作为连续流中化学酶级联的反应介质

• 批准号: 2746474
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2746474
• 关键词: Deep; eutectic; solvents; reaction; media

Solvents tend to dominate the mass balance of manufacturing processes for fine chemicals and a large portion of their use is dedicated to intensive purification procedures. One of the major advantages of flow chemistry is the ability to perform multistep synthesis in a single continuous process which eliminates the need to purify intermediates. The combination of chemical catalysis and enzymatic catalysis in continuous flow has potential to realise unique processes for complex molecules and will be a key contributor for industry meeting net zero challenges. However, seamlessly telescoping these two forms of catalysis is difficult due to their divergent reaction conditions as chemical catalysis is typically performed in organic solvents and enzymatic catalysis often requires an aqueous environment. Deep eutectic solvents (DES) have arisen as reaction media that is mutually compatible with both chemo- and bio-catalysis and may enable new chemoenzymatic cascades to be developed in continuous flow. Additionally, DES are immiscible with most organic solvents which can be used to extract the products from the reaction mixture and allow the DES to be recycled in future reactions. This project focuses on the application of DES to facilitate chemoenzymatic cascades in continuous flow and will explore the use of inline purification technology such as liquid-liquid separators to recycle the DES throughout the process. It is envisaged the combination of multistep continuous flow synthesis and solvent recycling will lead to more sustainable processes for complex products.

溶剂往往在精细化学品制造过程的质量平衡中占主导地位，并且其大部分用途专用于密集的纯化程序。流动化学的主要优点之一是能够在单一连续过程中进行多步合成，从而消除了对纯化中间体的需要。化学催化和酶催化在连续流中的结合有可能实现复杂分子的独特工艺，并将成为工业应对净零挑战的关键贡献者。然而，由于化学催化通常在有机溶剂中进行，而酶催化通常需要水性环境，因此难以无缝地伸缩这两种形式的催化，因为它们的反应条件不同。低共熔溶剂（DES）已经作为与化学催化和生物催化相互相容的反应介质出现，并且可以使新的化学酶级联在连续流中发展。此外，DES与大多数有机溶剂不混溶，这些有机溶剂可用于从反应混合物中萃取产物并允许DES在未来的反应中再循环。该项目的重点是DES的应用，以促进连续流中的化学酶级联，并将探索使用在线纯化技术，如液-液分离器，以在整个过程中回收DES。据设想，多步连续流合成和溶剂循环的组合将导致复杂产品的更可持续的工艺。