Development of a Novel in Vitro Vascular Model for Analysis of Blood Flow Through Medical Devices

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"Title: Development of a novel in vitro vascular model for analysis of blood flow through medical devices. Description: The aim of this PhD project is to develop an innovative, optically transparent, geometrically and physiologically representative 'phantom' of the human vasculature. This phantom will be used to capture haemodynamics using Particle Image Velocimetry (PIV) alongside conventional sensing technology (e.g. flow sensors). Currently, cardiovascular disease (CVD) is globally the leading cause of death. Graft development can be used to patch/repair a diseased or injured section of artery, or replace the diseased tissue entirely, overall it is a vital treatment option for many patients. A model is required to better understand CVD, allowing researchers to visualise blood flow though the vascular system. This will involve healthy, diseased and treated systems, to look for markers identifying arterial wall shear stress and relative residence time which can indicate problems with blood flow and cell degradation. Presently, this visualisation is executed using computer simulations, limited experimental setups and/or animal models. The new model produced during this PhD project could be used in the development of new treatments, replacing animal models and supporting computational simulations. With a clinical aim of being approved as a test and validation method for regulatory bodies such as the FDA and MRHA. "