Development of a Novel in Vitro Vascular Model for Analysis of Blood Flow Through Medical Devices

题目：一种新型体外血管模型的发展，用于分析通过医疗设备的血流。描述：这个博士项目的目的是开发一种创新的、光学透明的、几何上和生理上具有代表性的人体脉管系统“幻影”。该模型将用于使用粒子图像测速（PIV）和传统传感技术（例如流量传感器）来捕获血液动力学。目前，心血管疾病（CVD）是全球死亡的主要原因。移植物发育可用于修补或修复病变或受伤的动脉部分，或完全替换病变组织，总体而言，它是许多患者的重要治疗选择。需要一个模型来更好地理解心血管疾病，使研究人员能够可视化血液在血管系统中的流动。这将涉及健康的、患病的和治疗过的系统，寻找识别动脉壁剪切应力和相对停留时间的标记，这些标记可以指示血液流动和细胞降解的问题。目前，这种可视化是通过计算机模拟、有限的实验设置和/或动物模型来执行的。在这个博士项目中产生的新模型可以用于开发新的治疗方法，取代动物模型和支持计算模拟。其临床目标是被FDA和MRHA等监管机构批准为一种测试和验证方法。”

"Title: Development of a novel in vitro vascular model for analysis of blood flow through medical devices. Description: The aim of this PhD project is to develop an innovative, optically transparent, geometrically and physiologically representative 'phantom' of the human vasculature. This phantom will be used to capture haemodynamics using Particle Image Velocimetry (PIV) alongside conventional sensing technology (e.g. flow sensors). Currently, cardiovascular disease (CVD) is globally the leading cause of death. Graft development can be used to patch/repair a diseased or injured section of artery, or replace the diseased tissue entirely, overall it is a vital treatment option for many patients. A model is required to better understand CVD, allowing researchers to visualise blood flow though the vascular system. This will involve healthy, diseased and treated systems, to look for markers identifying arterial wall shear stress and relative residence time which can indicate problems with blood flow and cell degradation. Presently, this visualisation is executed using computer simulations, limited experimental setups and/or animal models. The new model produced during this PhD project could be used in the development of new treatments, replacing animal models and supporting computational simulations. With a clinical aim of being approved as a test and validation method for regulatory bodies such as the FDA and MRHA. "