3D Noninvasive Temperature Estimation with Ultrasound

利用超声波进行 3D 无创温度估算

• 批准号: 7080491
• 负责人: R MARTIN ARTHUR
• 金额: $ 26.08万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-15 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7080491
• 关键词: animal tissue; bioimaging /biomedical imaging; cytotoxicity; dogs; histology; neoplasm /cancer thermotherapy; noninvasive diagnosis; swine; technology /technique development; temperature; three dimensional imaging /topography

DESCRIPTION (provided by applicant): In hyperthermia treatment of cancer, tumors are elevated to cytotoxic temperatures (41 - 45oC) in order to aid in their control. Noninvasive temperature imaging would enhance the ability to uniformly heat tumors at therapeutic levels. Our long-term goal is to produce 3-dimensional (3D) temperature maps in soft tissue, noninvasively, conveniently, and at low cost, with 0.5oC accuracy and 1cm3 resolution. Ultrasound is an attractive modality for this purpose. Changes in speed of sound, attenuation, and the location of echoes have been explored by others, but as yet not reduced to clinical practice. Here we plan to investigate changes in ultrasonic backscattered energy (CBE) with temperature to provide a foundation for judging the accuracy and spatial resolution of this approach. Previously, we predicted monotonic changes in CBE for certain sub wavelength scatterers. We have measured CBE values similar to our predictions in images of tissue that were compensated for apparent axial and lateral motion in the images. To extend this preliminary work performed with R21 funding we plan the following: 1) to validate our model for the temperature-dependent change in backscattered ultrasonic energy (CBE) from individual scatterers using histological studies, and to extend it by developing an efficient computational framework for estimating temperature-dependent CBE from simulated images of collections of scatterers; 2) to generate experimental data in order to characterize CBE as a function of temperature in 3D from ex vivo specimens and in 2D from in vivo preparations while identifying CBE effects that are dependent on the imaging system; and 3) to develop motion tracking algorithms to compensate for real and/or apparent motion that obscures the temperature dependence of CBE then calibrate CBE in motion-compensated images for temperature estimation. If changes in backscattered energy can be used to estimate temperature accurately and reliably, the benefits could be important for hyperthermia, other thermal therapies, and ultrasonic imaging in general. In vivo success of CBE temperature estimation in animal preparations through the proposed studies will serve as the foundation for the eventual generation of 3D temperature maps in soft tissue in a noninvasive, convenient, and low-cost way in clinical hyperthermia.

描述（由申请人提供）：在癌症的热疗治疗中，将肿瘤升高至细胞毒性温度（41 - 45 ℃），以帮助控制肿瘤。非侵入性温度成像将增强在治疗水平上均匀加热肿瘤的能力。我们的长期目标是在软组织中生成三维（3D）温度图，无创，方便，低成本，精度为0.5 ℃，分辨率为1cm 3。超声是用于此目的的有吸引力的模态。其他人已经探索了声速、衰减和回声位置的变化，但尚未应用于临床实践。在这里，我们计划调查的变化，超声背散射能量（CBE）与温度提供了一个基础，判断这种方法的准确性和空间分辨率。以前，我们预测的单调变化CBE某些子波长散射体。我们测量的CBE值与我们在组织图像中的预测相似，这些组织图像补偿了图像中的明显轴向和侧向运动。为了扩展利用R21基金进行的这项初步工作，我们计划以下内容：1）使用组织学研究来验证我们的模型，用于来自单个散射体的背散射超声能量（CBE）的温度依赖性变化，并通过开发用于从散射体集合的模拟图像估计温度依赖性CBE的有效计算框架来扩展它; 2）生成实验数据，以便在3D中从离体样本和在2D中从体内制剂表征CBE作为温度的函数，同时识别依赖于成像系统的CBE效应;以及3）开发运动跟踪算法以补偿模糊CBE的温度依赖性的真实的和/或视在运动，然后校准运动补偿图像中的CBE以进行温度估计。如果背散射能量的变化可以用来准确可靠地估计温度，那么这种好处对于热疗、其他热疗法和超声成像来说都是重要的。通过所提出的研究在动物制备中CBE温度估计的体内成功将作为最终在临床热疗中以无创、方便和低成本的方式在软组织中生成3D温度图的基础。