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Developing the Alga Euglena Gracilis as a Source of Vegan Omega Oils and Other High Value Compounds

开发藻类眼虫作为纯素欧米茄油和其他高价值化合物的来源

基本信息

批准号：
2748026
负责人：
金额：
--
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2748026
关键词：
Developing Alga Euglena Gracilis Source

项目摘要

This project will work with an industrial collaborator to gain in depth training in algal culturing and strain improvement, chemical analysis and metabolomics. Supervisors: Ellis O'Neill (University of Nottingham) and John Macdonald and Donal McGee (AlgaeCytes Limited) Omega oils or Polyunsaturated Fatty Acids (PUFAs) are deemed essential for human health; however, the human body does not naturally produce them but must get them from other food sources such as wild-catch deep sea fish or other marine animals, with a global market of almost $2 billion in 2019. Omega 3 oils in algal oil are nutritionally equivalent to fish oil and can replace oils derived from marine animals. This project will develop the use of the alga Euglena gracilis for production of these oils and investigate high value co-products to improve the economic viability of these production systems. This project is a new collaboration, combining the expertise in the O'Neill lab in algal metabolism and the translational expertise in AlgaeCytes to take the fundamental knowledge of algal metabolism to trial commercial production and evaluate the economic viability of a Euglena based vegan Omega oil. This project brings together the experience and knowledge of the O'Neill lab in growth and metabolism in Euglena and AlgaeCytes' expertise in industrial production and exploitation of freshwater algae.This research program will involve optimising the growth of Euglena gracilis for production of the Omega oils and analysing the co-products, followed by strain improvement, using mutagenesis and cell sorting. This will be followed by an industrial placement at AlgaeCytes' base in Kent, optimising the growth conditions with the onsite technology and monitoring the product yields.

该项目将与工业合作者合作，以获得藻类培养和菌株改良，化学分析和代谢组学方面的深入培训。主管：Ellis奥尼尔（诺丁汉大学）和John Macdonald和Donal McGee（AlgaeCytes Limited）认为欧米茄油或多不饱和脂肪酸（PUFA）对人类健康至关重要;然而，人体不会自然产生它们，而是必须从其他食物来源获得它们，如野生捕捞的深海鱼或其他海洋动物，2019年全球市场近20亿美元。海藻油中的欧米茄3油在营养上与鱼油相当，可以替代海洋动物油。该项目将开发利用纤细裸藻生产这些油，并研究高价值的副产品，以提高这些生产系统的经济可行性。该项目是一个新的合作，结合了奥尼尔实验室在藻类代谢方面的专业知识和AlgaeCytes的转化专业知识，将藻类代谢的基本知识用于试验商业生产，并评估基于裸藻的纯素欧米茄油的经济可行性。该项目汇集了奥尼尔实验室在裸藻生长和代谢方面的经验和知识，以及AlgaeCytes在工业生产和淡水藻类开发方面的专业知识。该研究计划将涉及优化Euglena gracilis的生长以生产Omega油并分析副产品，然后使用诱变和细胞分选进行菌株改良。随后将在AlgaeCytes位于肯特的基地进行工业布局，利用现场技术优化生长条件并监控产品产量。