BEAUMONT/DETROIT CONTINENCE TREATMENT CENTER

博蒙特/底特律失禁治疗中心

• 批准号: 7251658
• 负责人: ANANIAS C DIOKNO
• 金额: $ 8.74万
• 依托单位: WILLIAM BEAUMONT HOSPITAL RESEARCH INST
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2006-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7251658
• 关键词: behavioral /social science research tag; behavioral medicine; clinical research; comorbidity; cooperative study; data collection methodology /evaluation; diabetes mellitus; female; human subject; human therapy evaluation; longitudinal human study; medical outreach /case finding; obesity; outcomes research; pregnancy; quality of life; racial /ethnic difference; satisfaction; technology /technique development; urinary incontinence; urinary tract disorder chemotherapy; urinary tract disorder diagnosis; urinary tract surgery

One of the major goals of this project is to determine the long term effects and outcomes including complications of the' most commonly used surgical procedures for urinary incontinence. Extensive review of the literature shows that the success rate (continence) and improvement rate appear to be similar among all of the three surgical techniques proposed in this CTC. Although the complications may be more unique with one or the other, it also appears that the morbidity rate is similar. Therefore, we do not believe that a power calculation can be performed to estimate the total number of subjects needed to be enrolled in each group. Therefore, we believe that the total number of subjects may have to be arbitrarily decided by the network to assure an adequate number of patients to be observed to gather all the necessary information to satisfy the objectives of this study. The principal goal of incontinence therapy is to improve the quality of life for the patient. Patient satisfaction in long-term follow-up has not been adequately reported in the literature. This study can provide the extensive review of these issues. However, the criteria on which the comparisons are made will necessarily be agreed upon by the collective investigators. In addition, the economics of the proposed procedures will also have a bearing on the overall medicoeconomic outcomes. Due to the similarities between the reported treatment success rates, differences in long term cost effectiveness and ultimate patient satisfaction may be a better predictor of overall treatment success than improvement of incontinence symptoms alone.

该项目的主要目标之一是确定长期的影响和结果，包括“最常用的尿失禁手术程序的并发症。广泛的文献综述表明，在本CTC中提出的所有三种手术技术中，成功率和改善率似乎相似。虽然一种或另一种的并发症可能更独特，但发病率似乎也相似。因此，我们认为无法进行把握度计算来估计每组需要入组的受试者总数。因此，我们认为，受试者总数可能必须由网络任意决定，以确保观察足够数量的患者，从而收集所有必要信息，以满足本研究的目的。失禁治疗的主要目标是提高患者的生活质量。文献中尚未充分报告长期随访中的患者满意度。本研究可以为这些问题提供广泛的回顾。然而，进行比较的标准必须由集体调查人员商定。此外，拟议程序的经济性也将对整体医学经济学结果产生影响。由于报告的治疗成功率之间的相似性，长期成本效益和最终患者满意度的差异可能是整体治疗成功的更好预测因素，而不是单独改善失禁症状。