Mechanisms of Energy Balance and Cancer Prevention
能量平衡与癌症预防的机制
基本信息
- 批准号:6983720
- 负责人:
- 金额:$ 247.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-09-23 至 2010-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant):
We propose in the Seattle TREC Center to elucidate the pathways linking components of energy balance to the cancer process using several different study designs, with the transdisciplinary contributions of scientists from medicine, cell biology, animal models, epidemiology, nutrition, gastroenterology, molecular biology, obesity, endocrinology, obesity, cardiology, immunology, biostatistics, mathematics, exercise physiology, and behavioral science. The overarching theme of the Seattle TREC Center will be determining the mechanisms by which energy balance modifies and influences the process of carcinogenesis across the lifespan in a broad range of settings including cell culture, animal models, small-scale human experimental studies, and population-level experimental work. In Project 1 we will bring together basic research efforts underway in our laboratories in an innovative approach to analyzing the cellular effects of hyperglycemia, hyperinsulinemia, and inflammation on growth, proliferation and survival pathways relevant to oncogenesis. In Project 2 we will determine, in an animal model, the effects of caloric restriction and exercise, alone and in combination, on the carcinogenic response in the mammary gland and on the mechanisms by which changes in energy balance modulate the development of cancer. In Project 3 we will investigate the metabolic and cancer biomarker response to experimental high and low glycemic load diets in lean and obese teenagers and young adults in a crossover clinical trial design. Within a randomized controlled trial in Project 4, we will investigate the effects of dietary weight loss and exercise, alone and together, on biomarkers of inflammation, and DNA damage and repair, and the influences of genetic polymorphisms on these associations. In Project 5 we will test a worksite obesity prevention intervention in a geographic area with large representation of low income and minority individuals on body mass index and markers of insulin resistance and inflammation. Our novel laboratory work will include testing intervention effects on serum proteomics and, in a developmental project, on metabolomics, in order to identify biological signals of dietary, exercise, and adiposity. Our investigators have a wealth of expertise in the components of the energy balance and cancer equation, and will provide important scientific leadership, training, and contributions to the overall TREC program.
描述(由申请人提供):
我们建议在西雅图TREC中心使用几种不同的研究设计来阐明将能量平衡的组成部分与癌症过程联系起来的途径,其中包括来自医学、细胞生物学、动物模型、流行病学、营养学、胃肠病学、分子生物学、肥胖症、内分泌学、肥胖症、心脏病学、免疫学、生物统计学、数学、运动生理学和行为科学的科学家的跨学科贡献。西雅图TREC中心的首要主题是确定能量平衡在广泛的环境中改变和影响整个生命周期中致癌过程的机制,包括细胞培养,动物模型,小规模人类实验研究和人口水平的实验工作。在项目1中,我们将汇集我们实验室正在进行的基础研究工作,以创新的方法分析高血糖症,高胰岛素血症和炎症对与肿瘤发生相关的生长,增殖和生存途径的细胞影响。在项目2中,我们将确定,在动物模型中,热量限制和运动的影响,单独和组合,在乳腺的致癌反应和能量平衡的变化调节癌症的发展的机制。在项目3中,我们将在交叉临床试验设计中研究瘦和肥胖青少年和年轻人对实验性高和低血糖负荷饮食的代谢和癌症生物标志物反应。在项目4的随机对照试验中,我们将研究饮食减肥和运动单独和共同对炎症生物标志物、DNA损伤和修复的影响,以及遗传多态性对这些关联的影响。在项目5中,我们将在一个地理区域测试一种工作场所肥胖预防干预措施,该地理区域具有大量低收入和少数民族个体的体重指数和胰岛素抵抗和炎症标志物。我们新的实验室工作将包括测试干预对血清蛋白质组学的影响,并在一个发展项目中,对代谢组学的影响,以确定饮食,运动和肥胖的生物信号。我们的研究人员在能量平衡和癌症方程的组成部分方面拥有丰富的专业知识,并将为整个TREC计划提供重要的科学领导,培训和贡献。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anne M. McTiernan其他文献
Anne M. McTiernan的其他文献
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{{ truncateString('Anne M. McTiernan', 18)}}的其他基金
Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
维生素 D 对女性行为减肥过程中身体成分的影响
- 批准号:
8449110 - 财政年份:2012
- 资助金额:
$ 247.28万 - 项目类别:
Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
维生素 D 对女性行为减肥过程中身体成分的影响
- 批准号:
8302790 - 财政年份:2012
- 资助金额:
$ 247.28万 - 项目类别:
Weight Loss & Cancer Biomarkers in Women: 0xidative Stress & Inflammation
减肥
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8245464 - 财政年份:2012
- 资助金额:
$ 247.28万 - 项目类别:
Weight Loss & Cancer Biomarkers in Women: 0xidative Stress & Inflammation
减肥
- 批准号:
8629621 - 财政年份:2012
- 资助金额:
$ 247.28万 - 项目类别:
Weight Loss & Cancer Biomarkers in Women: 0xidative Stress & Inflammation
减肥
- 批准号:
8459442 - 财政年份:2012
- 资助金额:
$ 247.28万 - 项目类别:
Weight Loss & Exercise Effects on Telomere Length in Postmenopausal Women
减肥
- 批准号:
8028105 - 财政年份:2010
- 资助金额:
$ 247.28万 - 项目类别:
Weight Loss & Exercise Effects on Telomere Length in Postmenopausal Women
减肥
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8206548 - 财政年份:2010
- 资助金额:
$ 247.28万 - 项目类别:
Effect of exercise and weight loss on adipose tissue biology
运动和减肥对脂肪组织生物学的影响
- 批准号:
7615661 - 财政年份:2008
- 资助金额:
$ 247.28万 - 项目类别:
Mechanisms of Energy Balance and Cancer Prevention
能量平衡与癌症预防的机制
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8135130 - 财政年份:2005
- 资助金额:
$ 247.28万 - 项目类别:
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