CNS Mechanisms Linking Exercise Training with Energy Balance and Metabolism

将运动训练与能量平衡和新陈代谢联系起来的中枢神经系统机制

• 批准号: 10242067
• 负责人: JOEL K. ELMQUIST
• 金额: $ 195.64万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242067
• 关键词: Address; Animal Model; Behavioral; Body Composition; Brain; Cell Nucleus; Communication; Disease; Eating; Electrophysiology (science); Energy Metabolism; Exercise; Genetic; Glutamates; Goals; Grant; Histologic; Histology; Hormones; Hypertension; Hypothalamic structure; Individual; Injections; Laboratories; Lead; Link; Liver; Malignant Neoplasms; Mediating; Metabolic; Metabolism; Modeling; Molecular; Mus; Neuraxis; Neuroanatomy; Neurons; Non-Insulin-Dependent Diabetes Mellitus; Nuclear Receptors; Obesity; Organ; Peptides; Peripheral; Physiological; Plasma; Pro-Opiomelanocortin; Property; Protocols documentation; Regulation; Research Design; Research Personnel; Rhodopsin; Role; SF1; Series; Services; Signal Transduction; Standardization; Synapses; System; Testing; Tissues; Training; Validation; base; blood glucose regulation; endurance exercise; energy balance; exercise training; experimental study; feeding; ghrelin; glucagon-like peptide 1; human subject; improved; innovation; insight; insulin sensitivity; metabolic phenotype; mouse model; multidisciplinary; neuronal circuitry; neurotransmission; physical inactivity; predictive modeling; programs; response; tool

ABSTRACT We have assembled a multidisciplinary team of investigators to investigate how the brain and key peripheral metabolic signals regulate feeding and glucose homeostasis following exercise. In particular, we have developed a program focused on using unique, genetic mouse models to understand why exercise training improves multiple metabolic parameters including insulin sensitivity and changes in body composition. We propose a set of projects that revolve around the hypothesis that several of these exercise-associated effects are mediated by changes in key brain circuits. The investigators involved in this application, Elmquist, Betley Zigman, and Williams bring distinct and synergistic expertise to the table. The Elmquist/Betley group will investigate the role of the ventromedial hypothalamus nucleus (VMH) neurons in the regulation of metabolic changes induced by exercise. The Zigman group will investigate the physiological importance of ghrelin signaling in regulating responses to exercise. The Williams group will investigate the changes in fundamental cellular properties of hypothalamic neurons following exercise training These three tightly interwoven Projects will address a number of new aspects of inter-organ communication between the peripheral tissues and critical regions in the brain. Three Cores will support the three Projects in these efforts: A) Administrative Core; B) Mouse Exercise and Metabolic Phenotyping Core and the C) Neuroanatomy/Histology/Brain Injection Core. In summary, these innovative and synergistic studies will increase the understanding of how exercise training regulates key peripheral metabolic signals via changes in central nervous system circuits.

摘要