Pharmacology and Toxicology Core

- 本申请中提出的工作是癌症药理学大型研究的组成部分， 利用纳米技术开发新的治疗原则。纳米级颗粒和装置是 其大小与生物分子相似，并且可以容易地进入大多数细胞。我们操纵身体的能力， 这些粒子的化学和生物特性使研究人员能够设计和使用 用于药物递送的纳米颗粒，作为图像造影剂和用于诊断目的。科学家在这 该中心将生产纳米颗粒和设备，由新材料制成，用于 该中心将进行临床前毒理学，药理学和疗效测试的纳米 使用动物模型和培养的人类细胞系的设备。的药理学和毒理学评估 这些颗粒在动物模型中的应用是其临床前开发的重要步骤。的使命 药理学和毒理学资源（PTR）将提供GLP药代动力学（PK）， 使用试验级联为中心研究者提供药效学（PD）和毒理学（TOX）服务 和协议开发的纳米技术表征实验室癌症研究， 结合

-The work proposed in this application is an integral part of a large research in cancer pharmacology directed at the development of new therapeutic principles using nanotechnology. Nanoscale particles and devices are similar in size to biomolecules and can easily enter most cells. Our ability to manipulate the physical, chemical, and biological properties of these particles affords researchers the ability to engineer and use nanoparticles for drug delivery, as image contrast agents, and for diagnostic purposes. Scientists in this Center will be generating nanoscale particles and devices, made out of novel materials that are intended for use in man. The Center will perform preclinical toxicology, pharmacology, and efficacy testing of nanoscale devices using animal models and cultured human cell lines. Pharmacologic and toxicologic assessment of these particles in animal models is an essential step in their preclinical development. The mission of Pharmacology and Toxicology Resource (PTR) will be to provide GLP pharmacokinetic (PK), pharmacodynamic (PD) and toxicologic (TOX) services to Center investigators utilizing the assay cascade and protocols developed by the Nanotechnology Characterization Laboratory for Cancer Research in conjunction with the