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Investigating the cellular effects of external environmental stressors on human skin circadian rhythm

研究外部环境压力源对人体皮肤昼夜节律的细胞影响

基本信息

批准号：
2748534
负责人：
金额：
--
依托单位：
Newcastle University
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2748534
关键词：
Investigating cellular effects external environmental

项目摘要

Skin has its own independent internal clock. This is driven by the circadian rhythm genes which modulate a diurnal pattern of skin protection from external stressors during the day and damage repair during the night. Extrinsic skin ageing is driven to a large extent by environmental factors and external stressors such as the components of sunlight, pollution and lifestyle factors. The damage from these exogenous sources and current lifestyle in the 21st century can impair skin structure, the skin's internal clock and related functions. The Birch-Machin laboratory has recently explored the role of individual and combined components of the full spectrum in solar light on human skin1. They have shown synergistic interactions of the individual sunlight components of sunlight with direct effects of urban pollution and topical actives on bioenergy and mitochondrial function1-3. The project will investigate the protection and repair against the damage induced by external stressors and thereby offer the potential for modifying the skin clock. This project is multi-disciplinary including cellular, molecular biological and physiological techniques, image analysis, cell culture, genetic and chemical analysis, immunostaining and gene expressionReferences:1FASEB BioAdvances 2021;3:855-865, 2Aging Cell. 2020 Oct;19(10):e13248, 3FASEB 2020 Mar; 34(3):3874-3883.

皮肤有自己独立的内部时钟。这是由昼夜节律基因驱动的，昼夜节律基因在白天调节皮肤保护免受外部压力的昼夜模式，并在夜间进行损伤修复。外在的皮肤老化在很大程度上是由环境因素和外部压力因素驱动的，例如阳光、污染和生活方式因素的成分。来自这些外源性来源和21世纪世纪的当前生活方式的损害会损害皮肤结构、皮肤的内部生物钟和相关功能。Birch-Machin实验室最近探索了太阳光中全光谱的单个和组合成分对人体皮肤的作用。他们已经显示了阳光的单个阳光组分与城市污染和局部活性物质对生物能量和线粒体功能的直接影响的协同相互作用1 -3。该项目将研究保护和修复外部压力引起的损伤，从而提供修改皮肤时钟的可能性。该项目涉及多学科，包括细胞、分子生物学和生理学技术、图像分析、细胞培养、遗传和化学分析、免疫染色和基因表达参考文献：1FASEB BioAdvances 2021;3：855-865，2Aging Cell。2020年10月;19（10）：e13248，3FASEB 2020年3月; 34（3）：3874-3883。