Impact of formulation composition on efficacy and properties of LNPs for delivery

基于纳米医学的疗法(包括基于RNA的疫苗)在国家和全球医疗保健中发挥着关键作用。为了有效，这些疫苗必须配制有递送系统，而脂质纳米粒是目前最有效的系统。然而，对脂质纳米粒制剂缺乏详细的了解。因此，该项目旨在解决这一问题，并确保我们拥有提供下一代RNA疫苗的知识、经验和专业知识。该项目的目的是开发LNPs，并研究配方差异对物理囊泡特性和生物学性能的评估。这将侧重于调整脂质纳米粒(LNPs)的组成，以改善药物输送效率和制剂性能。这将涉及脂类纳米药物配方、表征和微流控制造领域的学术研究和行业经验。以及许多LNP生产和分析技术的培训。这个学生将以SIPBS为基础，以一个成熟的小组为基础，拥有广泛的设施，包括提供这项研究所需的所有资源。学生将完成他们的PGCert。该团队在各自领域拥有世界领先的专业知识，佩里实验室将为学生提供疫苗配方、疫苗特性和分析方面的广泛培训。这一博士项目将提供独特的、多学科和跨部门的培训方案，以培养和装备早期研究人员开发新疫苗所需的技能和创业精神。

Nanomedicine based therapeutics (including RNA-based vaccines) play a pivotal role in national and global healthcare. To be effective, these vaccines must be formulated with delivery systems, and lipid nanoparticles are currently the most effective system. However, there is a lack of detailed understanding of the lipid nanoparticle formulation. Therefore, this project aims to address this and ensure that we have the knowledge, experience, and expertise to deliver the next generation of RNA vaccines. The aim of this project is to develop LNPs and investigate formulation differences on physical vesicle properties and the assessment of biological performance. This will focus on adjusting lipid nanoparticle (LNPs) composition to improve drug delivery efficacy and formulation properties.This will involve academic research and industry experience in the fields of lipid nanomedicine formulation, characterisation and microfluidic manufacturing. As well as training in many LNP production and analytical techniques.This studentship will be based in SIPBS in a well-established group with extensive facilities which include all required resources to deliver on this research. The student will complete their PGCert. This team has world-leading expertise in their fields, and the Perrie laboratory will provide the student with extensive training in vaccine formulation, characterisation and analysis of vaccines. This PhD programme will deliver a unique, multidisciplinary and intersectoral training programme to develop and equip the early-stage researchers with the required skills and entrepreneurship to develop new vaccines.