Cognitive Pathways to Disability

导致残疾的认知途径

• 批准号: 7174047
• 负责人: MICHELLE C CARLSON
• 金额: $ 5.76万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7174047
• 关键词: aging; body physical activity; clinical research; cognition; cognition disorders; epidemiology; female; functional ability; human old age (65+); human subject; memory; pathologic process; psychomotor function

DESCRIPTION (provided by applicant): Converging lines of evidence suggest that age-related changes in cognition, and particularly, executive function may exert downstream effects on physical function. However, there is a paucity of data regarding the role of these functions in the natural history of physical disability. We propose to address this gap by building on an established ongoing prospective cohort study of initially high-functioning women, aged 70-80 at baseline, the Women's Health and Aging Study II (WHAS II). Thus, our first aim of this ancillary study is to characterize rates of change in various domains of cognitive function over a 9-year interval. Less clear is whether these changes in cognition predict performance-based changes and self-reported transitions to preclinical difficulty independent of the well-studied mobility pathway. Thus, our second aim will be to test the value of a cognitive pathway to preclinical difficulty and disability in three groups of functional outcomes, categorized according to the putative demands they place on mobility, cognition, or both pathways. Our third set of aims will parallel the WHAS II's innovative efforts to assess preclinical functional difficulty in the mobility pathway by developing more valid and sensitive assessment method to better capture functional changes and compensations in complex activities of daily living typically not reported using standard self-report methods. Our fourth aim seeks to translate these epidemiologic findings into clinical terms by exploring how threshold relationships between cognition and physical function correspond to standard clinical indices of cognitive impairment. The WHAS II offers a unique opportunity to explore in-depth causal pathways between cognition and progression to physical disability for numerous reasons. The majority of women have been retained and evaluated over repeated intervals using state-of-the-art self-report measures comprehensive assessments of mobility, basic, and complex physical functions, and, a uniquely enriched cognitive protocol, developed extensively by the principal investigator. We will synthesize research findings from this study toinform the broader aims of the WHAS II renewal study to develop a conceptual framework that prospectively identifies precursors and major pathways in the natural history of disability. Understanding the roles that cognition may play in the transitions to disability will provide opportunities for better identifying at-risk individuals and developing targeted primary and secondary preventive interventions.

描述(由申请人提供)：各种证据表明，与年龄相关的认知变化，特别是执行功能的变化，可能会对身体功能产生下游影响。然而，关于这些功能在身体残疾的自然历史中的作用的数据很少。我们建议通过建立一项正在进行的对初始年龄在70-80岁之间的高功能女性的前瞻性队列研究来解决这一差距，这项研究名为妇女健康与老龄化研究II(WHAS II)。因此，我们这项辅助研究的第一个目标是描述9年间认知功能不同领域的变化率。不太清楚的是，这些认知变化是否预测了基于表现的变化和自我报告的向临床前困难的转变，而不是依赖于充分研究的活动途径。因此，我们的第二个目标将是在三组功能结果中测试一条通往临床前困难和残疾的认知路径的价值，这三组功能结果根据他们对活动能力、认知或两种路径的假定需求进行分类。我们的第三套目标将与WHAS II的创新努力平行，通过开发更有效和更敏感的评估方法来评估活动路径中的临床前功能困难，以更好地捕捉复杂日常生活活动中的功能变化和补偿，通常不使用标准的自我报告方法。我们的第四个目标是探索认知和身体功能之间的阈值关系如何与认知障碍的标准临床指标相对应，从而将这些流行病学发现转化为临床术语。WHAS II提供了一个独特的机会来深入探索认知和身体残疾进展之间的因果关系，原因很多。使用最先进的自我报告测量对移动性、基本和复杂的身体功能的全面评估，并使用由首席研究员广泛开发的独特丰富的认知方案，在重复的间隔时间内保留和评估大多数女性。我们将综合这项研究的研究结果，为WHAS II更新研究的更广泛目标提供信息，以制定一个概念框架，前瞻性地确定残疾自然历史中的先兆和主要途径。了解认知在向残疾转变过程中可能发挥的作用将为更好地识别高危个人和制定有针对性的一级和二级预防干预措施提供机会。

项目成果

Low serum potassium in mid life associated with decreased cerebrospinal fluid Abeta42 in late life.

中年低血清钾与晚年脑脊液 Abeta42 减少相关。

• DOI: 10.1097/01.wad.0000201848.67954.7d
• 发表时间: 2006
• 期刊: Alzheimer disease and associated disorders
• 影响因子: 2.1
• 作者: Mielke,MichelleM;Zandi,PeterP;Blennow,Kaj;Gustafson,Deborah;Sjögren,Magnus;Rosengren,Lars;Skoog,Ingmar
• 通讯作者: Skoog,Ingmar

Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer's disease?

• DOI: 10.2217/clp.12.59
• 发表时间: 2012-10
• 期刊: Clinical lipidology
• 作者: Mielke MM;Haughey NJ
• 通讯作者: Haughey NJ