Smart Hip Implants with Modified Biological Surface

具有改良生物表面的智能髋关节植入物

• 批准号: 7056131
• 负责人: JAVAD None PARVIZI
• 金额: $ 8.75万
• 依托单位: ROTHMAN INSTITUTE.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7056131
• 关键词: antibacterial agents; biomaterial development /preparation; biomaterial interface interaction; dogs; hip prosthesis; medical implant science; osteogenesis; postoperative complications; surface coating

DESCRIPTION (provided by applicant): This proposal describes a five-year training program for the development of a clinician-scientist. This collaborative research effort is intended to provide a stimulating training environment for the PI who is a fully trained orthopedic surgeon specializing in joint reconstruction. The proposal integrates internationally recognized investigators from various disciplines (Biochemistry, Bioengineering, Materials Science, Molecular Biology, Cell Biology, and Orthopedic Surgery) to use their expertise in training the PI and to address a pressing clinical problem. Despite extensive and effective measures, periprosthetic infection continues to affect 1-5 percent of joint replacements. With over 600,000 joint replacements being performed annually in the US and an expected rise in this number to exceed 1 million by the year 2030, periprosthetic infection poses a substantial economic and psychological burden to the healthcare and the patients. The objective of this research proposal is to develop a 'smart' prosthesis that addresses this important problem. Adhesion peptides (RGD) and antibiotic (Linezolid) will be linked directly to the surface of the titanium (Ti) implant to promote osseointegration and, on-demand, to control infection. In addition, the Ti will be covered with a thin, soluble sol-gel film that will release antibiotics to eradicate bacterial infections. The efficacy of the "smart" implant will be tested in a dog model to evaluate its bactericidal and osteogenic potential. The combination of early release and durable tethered antibiotic on the surface of the implant provides an effective antibacterial milieu around the hip that can minimize the incidence of early and late infections. The development of this technology will address a real need in orthopedic surgery in treating two of the most dreaded complications of arthroplasty, namely periprosthetic infection and osteolysis. As a result, patient pain, suffering and morbidity will be minimized.

描述（由申请人提供）：本提案描述了一个为期五年的培训计划，用于培养临床科学家。这项合作研究旨在为PI提供一个刺激的培训环境，PI是一名经过全面培训的关节重建专业骨科医生。该提案整合了来自不同学科（生物化学、生物工程、材料科学、分子生物学、细胞生物学和骨科手术）的国际公认的研究者，利用他们的专业知识培训PI并解决紧迫的临床问题。尽管采取了广泛有效的措施，但假体周围感染仍影响着1- 5%的关节置换术。在美国，每年进行超过600，000例关节置换术，预计到2030年，这一数字将超过100万例，假体周围感染给医疗保健和患者带来了巨大的经济和心理负担。这项研究计划的目标是开发一种“智能”假体，以解决这一重要问题。粘附肽（RGD）和抗生素（利奈唑胺）将直接连接到钛（Ti）植入物的表面，以促进骨整合，并按需控制感染。此外，钛将覆盖一层薄的可溶性溶胶-凝胶膜，该膜将释放抗生素以根除细菌感染。将在犬模型中测试“智能”植入物的有效性，以评价其杀菌和成骨潜力。植入物表面上的早期释放和持久拴系抗生素的组合在髋关节周围提供了有效的抗菌环境，可以最大限度地减少早期和晚期感染的发生率。这项技术的发展将解决骨科手术中治疗两种最可怕的关节成形术并发症（即假体周围感染和骨质溶解）的真实的需求。因此，患者的疼痛、痛苦和发病率将最小化。