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Infection Dynamics of Ehrlichia chaffeensis

恰菲埃里希体的感染动态

基本信息

批准号：
7008577
负责人：
ANDREA S VARELA-STOKES
金额：
$ 10.59万
依托单位：
UNIVERSITY OF GEORGIA
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-05-01 至 2008-01-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Dr. Varela's immediate career goal is to complete a doctorate in philosophy in Veterinary Parasitology at the University of Georgia, while simultaneously making original contributions to her field of study, specifically, tick-borne disease. This training will be the foundation for her long-term career plans to become an academic biomedical researcher. Having recently completed a D.V.M., supplemented with several research experiences in wildlife parasitology, she is well prepared and eager to further enhance her credentials through an intense, four-year mentored program leading to a doctorate degree in Medical Microbiology and Parasitology. This additional training at the University of Georgia will enable Dr. Varela to further hone her skills in molecular parasitology and experimental animal studies, which will be indispensable in allowing her to develop into an independent medical parasitologist. The overall objective of this proposal is to elucidate the infection dynamics of Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis and the most important emerging tick-borne disease in the southeastern United States, in the natural wild reservoir host, white-tailed deer. Our central hypothesis is that deer and ticks develop a persistent infection with E. chaffeensis that allows for the maintenance of this organism in nature, transmission to vector ticks, and subsequent creation of a human health risk. Our hypothesis of persistent infection will be tested by four specific aims: (1) understand the response to infection with multiple strains of E. chaffeensis in vitro and in vivo; (2) determine the degree of change in the level of organism following initiation of infection in deer and ticks; (3) identify the site of E. chaffeensis replication and maintenance in ticks; and (4) develop a monocyte primary cell culture in vitro model for investigating E. chaffeensis infection in different hosts. We are confident that the quality of the research environment at the University of Georgia, the critical mass of collaborating researchers focusing on the maintenance of ehrlichial organisms in nature, and the depth and breadth of background and training of her sponsor and co-sponsor create a strong research environment that will allow Dr. Varela to develop into an outstanding medical parasitologist and add to the understanding of tick-borne disease and human health.

描述（由申请人提供）：瓦雷拉博士的近期职业目标是在格鲁吉亚大学完成兽医寄生虫学哲学博士学位，同时对她的研究领域做出原创性贡献，特别是蜱传疾病。这项培训将是她成为一名学术生物医学研究人员的长期职业计划的基础。最近刚完成了D.V.M.，在野生动物寄生虫学的几个研究经验的补充下，她做好了充分的准备，并渴望通过一个激烈的，为期四年的指导计划，导致医学微生物学和寄生虫学博士学位，进一步提高她的凭据。在格鲁吉亚大学的这一额外培训将使瓦雷拉博士能够进一步磨练她在分子寄生虫学和实验动物研究方面的技能，这对于她成为一名独立的医学寄生虫学家至关重要。本提案的总体目标是阐明查菲埃立克体的感染动力学，人类单核细胞埃立克体病的病原体和美国东南部最重要的新出现的蜱传疾病，在自然野生水库主机，白尾鹿。我们的中心假设是，鹿和蜱发展为持续感染E。chaffeensis，允许该生物体在自然界中维持，传播给媒介蜱，并随后产生人类健康风险。我们的持续感染假说将通过四个具体目标进行检验：（1）了解多株E.（2）确定鹿和蜱感染后机体水平的变化程度;（3）确定E.（4）建立了研究查菲E.不同宿主的Chaffeensis感染。我们相信，格鲁吉亚大学的研究环境质量，合作研究人员的临界质量，专注于维护自然界中的埃里希体生物，她的赞助商和共同赞助商的背景和培训的深度和广度创造了一个强大的研究环境，使瓦雷拉博士能够发展成为一名杰出的医学寄生虫学家，并增加了对蜱虫的理解-传播疾病和人类健康。