Treatment/Substance Use Disorders/HIV Risk Reduction

治疗/药物滥用障碍/降低艾滋病毒风险

• 批准号: 7106437
• 负责人: GEORGE Edward WOODY
• 金额: $ 12.66万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-10 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106437
• 关键词: HIV infections; adolescence (12-20); alcoholism /alcohol abuse; behavior therapy; behavioral /social science research tag; buprenorphine; comorbidity; drug addiction; electrocardiography; fluoxetine; group counseling; hepatitis B; hepatitis C; high risk behavior /lifestyle; human subject; human therapy evaluation; immunopharmacology; mental disorder chemotherapy; methadone; motivation; naloxone; naltrexone; opiate alkaloid; patient oriented research; psychological adaptation; substance abuse related behavior; tuberculosis

DESCRIPTION (provided by applicant): This new Senior Scientist Award will free-up clinical time at the VA so I can continue my research on treatment outcome studies of persons with substance use disorders. My research career began in 1970 and since that time I have been P.I. on 17 grants and co-investigator on another 20 or more. Over the years my research activities have grown such that they conflict with clinical responsibilities that are necessary to maintain my VA salary, even though 75% of that time is for NIH and VA research. This award will allow me to reduce VA time to 5/8ths and reduce patient care and on-call responsibilities to 6 hours/week. Immediate plans are to continue projects that include 1) the Delaware Valley Node of the Clinical Trials Network (CTN) on which I am P.I. and responsible for 4 protocols: buprenorphine/naloxone for opioid dependent patients aged 14-21, motivational enhancement therapy, motivational incentives, and changes in treatment practices as a result of CTN participation; 2) studies on the long term course of HIV risk behavior among persons in and out of methadone treatment and the effect of methadone on immune function; 3) VA studies of patients who dropped out or were suspended from methadone treatment and of "Seeking Safety", a group therapy for veterans with substance use disorders and PTSD; and 4) studies in St. Petersburg, Russia comparing naltrexone with or without fluoxetine for relapse prevention and HIV risk reduction and of comorbidities between HIV, hepatitis B and C, TB and alcohol and drug dependence. Long term plans are to 1) submit a competing renewal of CTN studies in the Fall of '03; 2) implement a study of depot vs oral naltrexone in St. Petersburg; 3) help investigators in St. Petersburg and Porto Alegre, Brazil develop Centers for HIV prevention, treatment and research; and 4) submit a pilot study of buprenorphine for heroin addiction treatment of HIV+ and HIV- patients in Kiev, Ukraine. This work will be done at the University of Pennsylvania/Philadelphia VAMC Addiction Treatment Research Center, the Treatment Research Institute, and the Penn Center for AIDS Research where I have been an active participant since their beginnings.

描述（由申请人提供）： 这项新的高级科学家奖将在VA上释放临床时间，因此我可以继续研究对药物使用障碍患者的治疗结果研究。我的研究生涯始于1970年，从那时起，我一直是P.I.在另外20个或更多的20个以上的赠款和共同研究器上。多年来，我的研究活动已经发展，使它们与维持VA工资所必需的临床责任相抵触，即使有75％的时间用于NIH和VA研究。该奖项将使我能够将VA时间缩短为5/8，并将患者护理和待命责任降低到每周6小时。即时计划是继续项目，包括1）我是P.I.的临床试验网络（CTN）的特拉华谷节点。并负责4种方案：针对14-21岁的阿片类药物依赖性患者的丁丙诺啡/纳洛酮，动机增强疗法，动机激励措施以及由于CTN的参与而导致的治疗方法的变化； 2）研究美沙酮治疗中和外出的人之间艾滋病毒风险行为的长期过程以及美沙酮对免疫功能的影响； 3）VA研究对美沙酮治疗和“寻求安全”的患者的研究，这是对有药物使用障碍和PTSD的退伍军人的小组治疗； 4）在俄罗斯圣彼得堡进行的研​​究，比较了纳曲酮，有或没有氟西汀，以预防复发和艾滋病毒的风险降低以及HIV，HIV，乙型肝炎和C，TB，酒精以及酒精以及药物依赖性之间的合并症。长期计划是1）在03年秋季提交CTN研究的竞争续约； 2）在圣彼得堡实施对仓库与口服纳曲酮的研究； 3）帮助巴西圣彼得堡和阿雷格尔波尔图市的研究人员开发预防艾滋病毒，治疗和研究中心； 4）提交一项针对乌克兰基辅艾滋病毒+和艾滋病毒患者海洛因成瘾治疗的丁丙诺啡的试点研究。这项工作将在宾夕法尼亚大学/费城大学VAMC成瘾治疗研究中心，治疗研究所和宾夕法尼亚州艾滋病研究中心进行，自从他们开始以来我就一直是积极参与者。