PA-06-555 Senior Scientist Research and Mentorship Award (K05)

描述(由申请人提供)：这一竞争续签反映了我研究成瘾治疗的长期研究和职业目标，产生改善结果和减轻他人成瘾负担的信息，扩大国际成瘾研究，并指导年轻的成瘾研究人员职业生涯。为此，我与L合作研究了抗抑郁药物治疗、丙氧酚维持、美沙酮维持及其对艾滋病毒风险和感染的影响、LAAM、丁丙诺啡、心理疗法、艾滋病毒疫苗、艾滋病毒快速检测、巴西和俄罗斯的艾滋病毒与药物使用、俄罗斯和美国用于治疗海洛因成瘾并降低艾滋病毒风险的纳曲酮、继续使用阿片类药物的美沙酮患者、激励机制、动力增强，以及其他作为临床试验网络特拉华州山谷节点的P.I.的研究。我曾是NIDA研究部门、FDA药物滥用咨询委员会、DSM-IV药物滥用工作组、CPDD董事会和美国精神病学协会成瘾精神病学委员会的成员。我指导年轻的研究人员，为许多期刊审阅论文，是两本杂志的副主编，监督住院医生，参与医学生教学，并共同指导费城退伍军人管理局卓越中心的成瘾部分，直到2004年从退伍军人管理局退休。未来5年的研究活动包括：发表作为先前K奖焦点的丁丙诺啡青少年/年轻成人类阿片依赖者研究结果，完成我们小组目前参与的CTN研究，开展关于将药物滥用干预纳入初级保健的影响的CTN研究，在俄罗斯圣彼得堡完成一项纳曲酮植入研究和在基辅完成一项美沙酮研究，在圣彼得堡提交R01以研究纳曲酮植入剂与口服纳曲酮对艾滋病毒+海洛因成瘾者抗逆转录病毒药物依从性的影响，在乔治亚共和国发展一项每三周一次的针对亚布曲松成瘾的亚博克松研究。在巴西开展了减少患有多动症和大麻滥用或依赖的青少年艾滋病毒风险的Concerta研究，帮助制定了俄罗斯将成瘾和艾滋病毒治疗结合起来的指导方针，就初级保健中美沙酮的维持研究和丁丙诺啡植入物研究提供咨询，并制定了一项研究，以评估向出狱的阿片依赖者提供治疗的影响。目前的学员是两名退伍军人管理局/NIDA研究员、一名来自马来西亚的投资研究员和一名来自第比利斯的学员。教育活动包括监督宾夕法尼亚大学的一名居民，在宾夕法尼亚大学和退伍军人管理局主持案例会议，参加医学生成瘾课程，以及与国际合作者在研究主题上合作，包括研究设计、实施、质量保证程序、人类受试者保护、撰写论文，以及促进良好的临床实践。

DESCRIPTION (provided by applicant): This competing renewal reflects my long-term research and career objectives to study addiction treatment, generate information that improves outcome and reduces the burden of addiction on others, expand international addiction research, and mentor young investigators for addiction research careers. To this end, I have been PI or a Co-l on studies on antidepressant pharmacotherapy, propoxyphene maintenance, methadone maintenance and its impact on HIV risk and infection, LAAM, buprenorphine, psychotherapy, a HIV vaccine, a rapid HIV test, HIV and drug use in Brazil and Russia, naltrexone for treating heroin addiction and reducing HIV risk in Russia and the U.S., methadone patients who do not stop opioid use, motivational incentives, motivational enhancement, and others as P.I. of the Delaware Valley Node of the Clinical Trials Network (CTN). I have been a member of NIDA study sections, the FDA Drug Abuse Advisory Committee, the DSM-IV Substance Abuse Work Group, CPDD Board of Directors, and the Board of Addiction Psychiatry for the American Psychiatric Association. I mentor young investigators, review papers for many journals, am associate editor of two, supervise residents, participate in medical student teaching, and co-directed the addictions component of the Philadelphia VA Center of Excellence until retiring from the VA in 2004. Research activities for the next 5 years include publishing results of the buprenorphine study of adolescent/young adult opioid dependent individuals that was a focus of the prior K award, finishing CTN studies in which our group is currently participating, developing CTN studies on the impact of integrating substance abuse interventions in primary care, completing a naltrexone implant study in St. Petersburg Russia and a methadone study Kiev, submitting a R01 to study the impact of naltrexone implant vs. oral naltrexone on adherence to antiretroviral medication in HIV+ heroin addicts in St. Petersburg, developing a study of thrice weekly Suboxone for Subutex addiction in the Republic of Georgia, and a study of Concerta for reducing HIV risk in adolescents with ADHD and marijuana abuse or dependence in Brazil, helping develop guidelines for integrating addiction and HIV treatment in Russia, consulting on a study of methadone maintenance in primary care and a study of implant buprenorphine, and developing a study to assess the impact of offering treatment to opioid dependent persons being released from prison. Current mentees are two VA/NIDA fellows, an INVEST fellow from Malaysia, and a mentee from Tbilisi. Educational activities include supervising a Penn resident, leading case conferences at Penn and the VA, participating in an addiction course for medical students, and working with international collaborators on research topics including study design, implementation, procedures for quality assurance, human subjects protection, writing papers, and facilitating Good Clinical Practice.