Diet, Hormone Replacement Therapy and Breast Cancer

饮食、激素替代疗法和乳腺癌

• 批准号: 7114382
• 负责人: SHUMIN ZHANG
• 金额: $ 13.92万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-12 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114382
• 关键词: alcoholic beverage consumption; aspirin; breast neoplasms; caffeine; cancer prevention; clinical research; clinical trials; dietary fiber; estrogens; female; folate; hormone therapy; human subject; human therapy evaluation; longitudinal human study; nutrition aspect of cancer; nutrition related tag; patient oriented research; progestins; questionnaires; radioimmunoassay; tocopherols; women' s health

DESCRIPTION (provided by applicant): This is a resubmission of I K07 CA096619-01 "Diet, Hormone Replacement Therapy and Breast Cancer". Candidate: Shumin Zhang received her MD at the Harbin Medical University in 1986 and her ScD in epidemiology and nutrition at the Harvard School of Public Health in 1998. She then completed her post-doctoral training in 2000, and now is an Assistant Professor of Medicine at the Harvard Medical School (HMS). She applies for this Career Development Award to acquire the methodological and theoretical research skills needed to become an independent scientist in cancer and nutritional epidemiology. Sponsor and Environment: JoAnn Manson, MD, DrPH, is the Chief of the Division of Preventive Medicine at the Brigham and Women's Hospital, Professor of Medicine at the HMS and Co Principal investigator (Co-Principal Investigator) of the Women's Health Study ONHS). Julie Buring, ScD, is the Deputy Director of the Division, Professor of Ambulatory Care and Prevention at the HMS and Principal Investigator of the WHS. They have trained numerous investigators in the fields of diet, lifestyle and chronic diseases, areas in which they have published extensively. Research: We plan to conduct a prospective analysis within the WHS, an ongoing clinical trial of vitamin E and low-dose aspirin in the primary prevention of cancer and cardiovascular disease among 39,876 women. We will test 4 dietary hypotheses that moderate alcohol intake increases risk of breast cancer, whereas high intake of folate and fiber reduces risk; and caffeine intake is not associated with risk. We will link fiber intake to plasma endogenous sex steroid hormones in a subsample of the WHS. We will also test 4 hormone replacement therapy (HRT) hypotheses that tong-term use of estrogen plus progestin increases risk of breast cancer more than estrogen alone; estrogen plus cyclic progestin increases risk more than estrogen plus continuous progestin; low-dose estrogens confer lower risk than high-dose; and use of estrogen is more strongly associated with risk among women drinking alcohol. The ongoing WHS will provide updated and repeated measures of HRT, comprehensive dietary assessment at baseline, and important covariates for breast cancer in addition to follow-up of the cohort and documentation of breast cancer cases (expected N = 1550). The findings from this project could have direct clinical application for efforts to reduce risk of breast cancer.

描述(申请人提供)：这是I K07 CA096619-01“饮食、激素替代疗法与乳腺癌”的重新提交。候选人：张淑敏1986年在哈尔滨医科大学获得医学博士学位，1998年在哈佛大学公共卫生学院获得流行病学和营养学博士学位。2000年，她完成了博士后培训，现在是哈佛医学院(HMS)的医学助理教授。她申请了这一职业发展奖，以获得成为癌症和营养流行病学独立科学家所需的方法和理论研究技能。赞助商和环境：Joann Manson，医学博士，博士，布里格姆妇女医院预防医学部主任，HMS医学教授，NHS妇女健康研究联合首席研究员(联合首席研究员)。朱莉·布灵是卫生与公众服务部的副主任、卫生与公众服务部的门诊护理与预防教授，也是世界卫生组织的首席研究员。他们在饮食、生活方式和慢性病领域培训了大量的研究人员，他们在这些领域发表了大量的著作。研究：我们计划在WHS中进行一项前瞻性分析，这是一项正在进行的维生素E和低剂量阿司匹林在39876名女性中用于癌症和心血管疾病一级预防的临床试验。我们将测试4个饮食假设，即适量饮酒会增加乳腺癌的风险，而叶酸和纤维的高摄入量会降低风险；咖啡因的摄入量与风险无关。我们将在WHS的一个子样本中将纤维摄入量与血浆内源性类固醇激素联系起来。我们还将测试4种激素替代疗法(HRT)假设，即长期使用雌激素+孕激素比单独使用雌激素更能增加乳腺癌的风险；雌激素+环孕激素比雌激素+持续孕激素增加的风险更大；低剂量雌激素的风险比高剂量低；在饮酒的女性中，使用雌激素与风险的相关性更强。正在进行的WHS将提供最新和重复的HRT测量方法、基线的全面饮食评估和乳腺癌的重要协变量，以及对乳腺癌病例的队列跟踪和文件记录(预计N=1550)。该项目的发现可能对降低乳腺癌风险的努力具有直接的临床应用价值。