Modelling the progression of osteoarthritis via alterations to synovial fluid mechanobiology and microbiome

通过改变滑液力学生物学和微生物组来模拟骨关节炎的进展

• 批准号: 2749473
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2749473
• 关键词: Modelling; progression; osteoarthritis; via; alterations

Synovial fluid (SF) is our articular joint lubricant and shock absorber as well as the source of nutrients for avascular articular cartilage. Osteoarthritis (OA) is a degenerative disease that leads to irreversible damage of the joint. OA is the most common joint disease worldwide and it leads to severe pain and loss of joint function. Most OA-related research focuses on cartilage that wears down over time, however, it has been shown that multiple alterations of SF occur concomitantly during OA progression, among which significant variations in its chemical composition and lubricating properties. Additionally, although under normal physiological conditions, one expects the synovial space to be sterile, recent studies report the presence of micro-organisms, or microorganism-derived genetic material in the SF of both OA patients and more surprisingly healthy control subjects. The purpose of this project is to monitor SF microbiome alterations in situ (synovial pocket) and in real-time during OA progression. This project will not only help elucidate the relationship between microbiome composition, levels of inflammation, and viscosity of complex fluids but it will also reveal potential novel markers to track fluid alterations with multiple applications, especially for real-time OA monitoring and development of appropriate in-situ (drug delivery) treatment.

滑液（SF）是我们关节的润滑剂和减震器，也是无血管关节软骨的营养来源。骨关节炎（OA）是一种退行性疾病，可导致关节不可逆的损伤。OA是全球最常见的关节疾病，它导致严重的疼痛和关节功能丧失。大多数OA相关研究集中在软骨随着时间的推移而磨损，然而，已经表明，在OA进展期间伴随着SF的多种改变，其中其化学组成和润滑特性的显著变化。此外，尽管在正常生理条件下，人们预期滑膜空间是无菌的，但最近的研究报告了OA患者和更令人惊讶的健康对照受试者的SF中存在微生物或微生物衍生的遗传物质。本项目的目的是监测SF微生物组的原位（滑膜袋）变化，并在OA进展过程中实时监测。该项目不仅有助于阐明微生物组组成，炎症水平和复杂流体粘度之间的关系，而且还将揭示潜在的新型标记物，以跟踪多种应用中的流体变化，特别是用于实时OA监测和开发适当的原位（药物输送）治疗。