Core B-Clinical Data Collection and Management Core
核心 B-临床数据收集和管理核心
基本信息
- 批准号:10555683
- 负责人:
- 金额:$ 638.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-01 至 2028-02-29
- 项目状态:未结题
- 来源:
- 关键词:AddressAdherenceAlabamaBloodCalciumClinicClinicalClinical DataCollectionComplexCrystal FormationDataData CollectionDatabasesDegenerative polyarthritisDepositionDisease ProgressionElderlyEnrollmentEnsureExclusion CriteriaExerciseFrightGoalsImageImpairmentIncentivesIncidenceInfrastructureInstitutional Review BoardsIowaJointsKnee OsteoarthritisKnowledgeLeadLeadershipLifeMonitorNervous SystemObservational StudyOutcomeOutcome StudyPainParticipantPatient RecruitmentsPhasePhysical activityPrevalenceProceduresProteinsProteomicsProtocols documentationReportingResearchRisk FactorsSafetySiteSpecimenSynovial FluidUniversitiesVisitWorkadvanced diseaseclinical centerdata accessdata cleaningdata managementdata standardsdisabilitydisabling diseaseethnic minority populationexperiencefollow-uphigh riskinclusion criteriainsightmineralizationnovelparticipant safetyquality assuranceracial minority populationretention ratesample collectionsuccesstimeline
项目摘要
ABSTRACT Clinical Data Collection and Management Core
Knee osteoarthritis (OA) is among the world's most disabling diseases, and it accounts for a substantial
percentage of the increase in disability life years. The Multicenter Osteoarthritis (MOST) Study has made major
contributions to our understanding of the course of OA and identification of risk factors for its incidence and
progression. Beginning in 2003, the MOST initially enrolled 3026 participants with or at high risk of knee OA. In
the most recent phase (MOST3), an additional 1525 participants who were slightly younger and unlikely to have
advanced disease were enrolled. Despite the insights provided by the previous phases of MOST, there are still
no treatments available that slow progression of OA. The next phase (MOST4) focuses on three major scientific
projects that address key gaps in knowledge in OA. These projects include: Impaired Exercise-Induced
Hypoalgesia (Project 1); Synovial Fluid Proteomics (Project 2); and Intra-articular Mineralization (Project 3).
These projects will be supported by four Cores – the Administrative Core, the Imaging Core, the Analysis Core,
and the Clinical Data Collection and Management Core (CDCMC). The overarching goal of the CDCMC is to
ensure the success of the MOST projects by providing an outstanding infrastructure for visit enrollment, study
procedures and data collection, and longitudinal ascertainment of critical outcomes. This core includes the
Coordinating Center (led by Peggy Cawthon at UCSF) and the MOST clinical centers: University of Iowa (UI
clinic center lead: James Torner) and University of Alabama, Birmingham (UAB clinic center lead: Cora E.
Lewis). Specially, the aims of the CDCMC are to: 1) To enroll 2143 existing MOST participants, and 150 newly
recruited participants from underrepresented racial and ethnic minority groups, for the MOST4 V1 examination
(2293 total), and follow those participants for the MOST4 V2 examination, 2) Ensure the collection of high-quality
research data and specimens, 3) To maintain a high rate of retention of study participants and complete
ascertainment of study outcomes, 4) To ensure the safety of participants and to meet regulatory standards, 5)
Collect, clean, document and integrate MOST data across all projects and cores.
临床数据收集与管理核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Peggy Mannen Cawthon其他文献
Peggy Mannen Cawthon的其他文献
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{{ truncateString('Peggy Mannen Cawthon', 18)}}的其他基金
Novel Computed Tomography (CT) Imaging Biomarkers in Older Adults for Predicting Adverse Geriatric Health Outcomes
用于预测老年人不良健康结果的新型计算机断层扫描 (CT) 成像生物标志物
- 批准号:
10303313 - 财政年份:2021
- 资助金额:
$ 638.93万 - 项目类别:
Novel Computed Tomography (CT) Imaging Biomarkers in Older Adults for Predicting Adverse Geriatric Health Outcomes
用于预测老年人不良健康结果的新型计算机断层扫描 (CT) 成像生物标志物
- 批准号:
10458743 - 财政年份:2021
- 资助金额:
$ 638.93万 - 项目类别:
AMPLIFIed muscle mass in older cancer survivors enrolled in a diet-exercise program
参加饮食锻炼计划的老年癌症幸存者的肌肉质量增加
- 批准号:
10531199 - 财政年份:2019
- 资助金额:
$ 638.93万 - 项目类别:
AMPLIFIed muscle mass in older cancer survivors enrolled in a diet-exercise program
参加饮食锻炼计划的老年癌症幸存者的肌肉质量增加
- 批准号:
9888993 - 财政年份:2019
- 资助金额:
$ 638.93万 - 项目类别:
AMPLIFIed muscle mass in older cancer survivors enrolled in a diet-exercise program
参加饮食锻炼计划的老年癌症幸存者的肌肉质量增加
- 批准号:
10311067 - 财政年份:2019
- 资助金额:
$ 638.93万 - 项目类别:
Translational Epidemiology - Training for Research on Aging and Chronic disease
转化流行病学 - 老龄化和慢性病研究培训
- 批准号:
10641744 - 财政年份:2016
- 资助金额:
$ 638.93万 - 项目类别:
Translational Epidemiology - Training for Research on Aging and Chronic disease
转化流行病学 - 老龄化和慢性病研究培训
- 批准号:
10411498 - 财政年份:2016
- 资助金额:
$ 638.93万 - 项目类别:
Determination of Skeletal Muscle Mass by Creatine Dilution
肌酸稀释法测定骨骼肌质量
- 批准号:
8653228 - 财政年份:2013
- 资助金额:
$ 638.93万 - 项目类别:
Determination of Skeletal Muscle Mass by Creatine Dilution
肌酸稀释法测定骨骼肌质量
- 批准号:
8919080 - 财政年份:2013
- 资助金额:
$ 638.93万 - 项目类别:
Determination of Skeletal Muscle Mass by Creatine Dilution
肌酸稀释法测定骨骼肌质量
- 批准号:
8735074 - 财政年份:2013
- 资助金额:
$ 638.93万 - 项目类别:
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