CORE-- Toxiconetic Susceptibility

核心--毒物敏感性

• 批准号: 6875453
• 负责人: Stephen M Rappaport
• 金额: $ 2.45万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6875453
• 关键词: biomarker; biomedical facility; disease /disorder proneness /risk; environmental exposure; environmental health; environmental toxicology; epidemiology; gene environment interaction

Description (provided by applicant): The purpose of the Toxicokinetic Susceptibility Research Core (TSRC) is to foster collaboration and sharing of ideas, data and methods among the members in a manner that enhances existing Center projects and motivates proposals for future studies. The specific objectives of the TSRC are to: 1) Support and expand collaborative research involving the following loci: i) biomarkers of exposure and effect, ii) biologically-based modeling, and iii) hepatotoxicity, as well as research involving two or more of these areas. 2) Establish effective mechanisms for sharing ideas within and among focus groups and expanding Core membership to other relevant scientists. 3) Increase interactions with other Research and Facility Cores to foster application of sound toxicokinetic principles in study designs of Center members and affiliates.

描述（由申请人提供）：毒代动力学敏感性研究核心（TSRC）的目的是促进成员之间的合作和思想，数据和方法的共享，以加强现有的中心项目并激励未来研究的建议。TSRC的具体目标是：1）支持和扩大涉及以下位点的合作研究：i）暴露和效应的生物标志物，ii）基于生物学的建模，iii）肝毒性，以及涉及两个或更多这些领域的研究。2)建立有效的机制，在重点小组内部和之间分享想法，并将核心成员扩大到其他相关科学家。3)增加与其他研究和机构核心的互动，以促进在中心成员和附属机构的研究设计中应用合理的毒代动力学原则。