A Cost-Effective OPH Multilayer Modified Microcantilever for Detection of OPs

用于检测 OP 的经济有效的 OPH 多层改良微悬臂梁

• 批准号: 7109645
• 负责人: Karen XU
• 金额: $ 10万
• 依托单位: SENSACOIL, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7109645
• 关键词: biohazard detection; bioterrorism /chemical warfare; cost effectiveness; enzymes; microarray technology; monitoring device; organophosphorus insecticide; surface property; technology /technique development; thermodynamics; time resolved data

DESCRIPTION (provided by applicant): A particularly important national need exists for enhancing safety and security of environments ranging from residential structures, to subways, to airports, and to borders. Chemical warfare agents are 1 of the major threats to homeland security. Research that leads to a clear path for the development of low cost, fast, rugged, and extremely sensitive sensors for real-time monitoring is of high demand to homeland security. The goal of this research proposal is to develop extremely sensitive and highly selective microsensors for chemical warfare agents or simulants by using enzyme based layer-by-layer nanoassembly modified microcantilevers. The aim of the phase I of this project is to validate the feasibility of our technology for ultimate fabrication of microcantilever sensor devices. The specific aims include: (1) fabrication of a microchannel fluid cell, (2)Surface modification of microcantilevers, (3)Thermodynamic study. The ultimate goal in phase II will be to develop a handhold mierocantilever arrays based detection system for selective detection of known OP species with low false alarm rates. Requirements such as sensitivity, small size, automatic operation, low cost and ruggedness make the microcantilever sensor approach very attractive for homeland security and environment application. Potential customers for devices to be developed by the company include government agencies such as Homeland Security, Agriculture, EPA, Defense and the Postal Service, as well as similar state agencies. Examples of private customers include farms, water treatment plants, universities and hospitals.

描述（由申请人提供）：具有提高住宅结构，地铁，机场和边界等环境的安全性和安全性的国家需求特别重要。化学战代理是对国土安全部的主要威胁之一。导致开发低成本，快速，坚固且非常敏感的传感器以实时监控的清晰途径是对国土安全的需求。这项研究建议的目的是通过使用基于酶的逐层纳米隔板修饰的微型电视器为化学战剂或模拟物开发极敏感和高度选择性的微传感器。该项目的第一阶段的目的是验证我们技术对微型管理器传感器设备的最终制造的可行性。 具体目的包括：（1）制造微通道流体细胞，（2）微型磁管的表面修饰，（3）热力学研究。第二阶段的最终目标是开发基于handohostilever阵列的Handhold MierCantilever阵列，以选择性检测较低的错误警报率的已知OP物种。敏感性，小规模，自动操作，低成本和坚固性等要求使MicroCantilever传感器方法对国土安全和环境应用非常有吸引力。该公司开发的设备的潜在客户包括政府机构，例如国土安全，农业，EPA，国防和邮政服务以及类似的州机构。私人客户的例子包括农场，水处理厂，大学和医院。