Bio-Acrylic Acid Production from Seaweed (BAAPS)

每年约有630万吨丙烯酸，全球市场价值120亿美元，由丙烯（一种化石燃料衍生物）工业合成，作为纺织品，粘合剂，油漆等平台化学品。迄今为止，生物合成替代品对工业来说成本太高或效率太低。该项目旨在通过开发一种具有成本效益的藻类废物微生物生物合成途径来减少丙烯酸生产的碳排放。方法：-分子遗传学将用于产生专有的微生物菌株，其具有从养殖的大型藻类中存在的丰富代谢物中增强的生物丙烯酸生产。- 分析化学技术，如色谱法和质谱法，将用于量化这种高价值化学品的生产。- 将研究分批和最终在生物反应器设置中的生长条件，以优化它们产生的菌株的生物丙烯酸生产。- 将设计、测试和优化从培养菌株中提取丙烯酸的方法。

Annually ~6.3 million tonnes of acrylic acid, with a global market of $12 billion, is industrially synthesised from propylene (a fossil fuel derivative) as a platform chemical for e.g textiles, adhesives, paints. To date, biosynthetic alternatives are too costly or inefficient for industry. This project aims to reduce carbon emissions from acrylic acid production by developing a cost-effective microbial biosynthetic route from algal waste. Methodology:- Molecular genetics will be used to generate proprietary microbial strains with enhanced bio-acrylic acid production from abundant metabolites present in farmed macroalgae. - Analytical chemistry techniques, such as chromatography and mass spectroscopy, will be used to quantify production of this high-value chemical. - Growth conditions in batch and ultimately in bioreactor settings that optimise bio-acrylic acid production by the strains they generate will be investigated. - A method for acrylic acid extraction from the cultured strains will be devised, tested and optimised.