How do bacteria contribute to aggressive prostate cancer?

细菌如何导致侵袭性前列腺癌？

• 批准号: 2750975
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2750975
• 关键词: How; do; bacteria; contribute; aggressive

Prostate cancer (PCa) is the second most common cancer in men worldwide and ~307,000 men die every year. It is known that infectious agents, such as bacteria and viruses, are involved in the development of a variety of cancers such as cervical, stomach, and bladder cancer. The causes of PCa and the development of advanced disease remains obscure, but there is good evidence that infectious agents could be one cause.This project will examine the question of how infectious bacterial agents are involved in the development of PCa, or whether their presence is opportunistic. The project will sequence and identify potentially novel bacteria that are associated with a poor outcome; determine the associations between bacteria, aggressive disease, and human cancer cell changes by mining existing cancer and urine datasets; and investigate mechanisms of action between host and bacteria. This research has the potential to reveal how bacteria can be used to predict the best treatment to receive and reveal new treatment possibilities to prevent or halt aggressive cancer.

前列腺癌（PCa）是全球男性第二大常见癌症，每年约有307，000名男性死亡。已知感染因子，如细菌和病毒，参与多种癌症如宫颈癌、胃癌和膀胱癌的发展。前列腺癌的病因和晚期疾病的发展仍然不清楚，但有很好的证据表明，感染性病原体可能是一个原因。本项目将研究感染性细菌病原体如何参与前列腺癌的发展，或者它们的存在是否是机会性的。该项目将测序和识别与不良结果相关的潜在新型细菌;通过挖掘现有的癌症和尿液数据集来确定细菌，侵袭性疾病和人类癌细胞变化之间的关联;并研究宿主和细菌之间的作用机制。这项研究有可能揭示如何利用细菌来预测接受的最佳治疗，并揭示预防或阻止侵袭性癌症的新治疗可能性。