MECHANISMS OF HUMAN INSULIN RESISTANCE: BARIATRIC SURGERY

人类胰岛素抵抗的机制：减肥手术

• 批准号: 7380457
• 负责人: W Timothy GARVEY
• 金额: $ 0.45万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380457
• 关键词: MECHANISMS; HUMAN; INSULIN; RESISTANCE; BARIATRIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Insulin Resistance Syndrome (IR) provides the "common soil" for the development of type 2 diabetes and cardiovascular disease and is responsible for extensive morbidity and mortality in our society. Bariatric surgery (BS) offers an efficacious treatment for sustained weight loss for morbidly obese patients. The metabolic improvements associated with the surgical procedure include enhancement of insulin release, insulin resistance, and glucose utilization. The mechanisms underlying the improvement in insulin sensitivity in these patients are not understood, and may be related to the marked reduced caloric and macronutrient intake, as well as to the fat malabsportion induced by the procedure. Additionally, the BS model provides the opportunity to study the effect of bypassing most of the stomach and duodenum on the entero-insular axis, and its subsequent effects on different metabolic pathways as well as satiety regulatory mechanisms. Therefore, we want to expand the subjects' inclusion criteria in our current grant, to obese subjects who attain weight loss through BS. In accordance to our current hypotheses, the overall goal of this study will be to determine the effect of BS on insulin sensitivity, the entero-insular axis, and intramyocellular fat. Subjects receiving BS will be recruited for the study. The study will have 3-phases- Phase I: 1-4 wks before surgery; Phase II: 3-6 months after surgery; and Phase III: 12-18 months after surgery.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。胰岛素抵抗综合征（IR）为2型糖尿病和心血管疾病的发展提供了“共同土壤”，并对我们社会中广泛的发病率和死亡率负责。减肥手术（BS）为病态肥胖患者提供了一种持续减肥的有效治疗方法。与手术相关的代谢改善包括胰岛素释放、胰岛素抵抗和葡萄糖利用的增强。这些患者胰岛素敏感性改善的机制尚不清楚，可能与明显减少的热量和大量营养素摄入以及手术引起的脂肪吸收不良有关。此外，BS模型为研究绕过大部分胃和十二指肠对肠-岛轴的影响及其对不同代谢途径和饱腹感调节机制的影响提供了机会。因此，我们希望在我们目前的拨款中扩大受试者的纳入标准，以通过BS实现体重减轻的肥胖受试者。根据我们目前的假设，本研究的总体目标将是确定BS对胰岛素敏感性、肠-岛轴和细胞内脂肪的影响。接受BS治疗的受试者将被招募参加研究。该研究将分为三个阶段：第一阶段：手术前1-4周；II期：术后3-6个月；第三阶段：手术后12-18个月。